The recently released global crustal model CRUST 2.0 has been validated both globally and regionally focusing on its information content regarding the crust-mantle boundary. The numerical assessment of the metric information given by the database in terms of thickness and position of individual crustal layers with respect to sea level takes place by investigating correlations with the surface topography and by comparing those values with known theoretical approaches that describe the compensation mechanism between crust and mantle. The investigations described focused especially on the last crustal layer of CRUST 2.0, which represents the boundary surface between crust and mantle, widely known as Mohorovicic discontinuity. A direct comparison of the Moho structure as given from the crustal model CRUST 2.0 with the respective compensation depths derived theoretically from the application of the Airy/Heiskanen hypothesis is carried out both globally and regionally. The comparisons, especially those referring to selected regions of the globe expressing characteristic tectonic features, such as mountain belts or oceanic ridges, enable both the numerical assessment of the database while giving at the same time a preliminary insight on the local and regional behaviour of known isostatic mechanisms.