The presence of more than one solute diffused in fluid mixtures is very often requested for discussing the natural phenomena such as transportation of contaminants, underground water, acid rain and so on. In the paper, the effect of nonlinear thermal radiation on triple diffusive convective boundary layer flow of Casson nanofluid along a horizontal plate is theoretically investigated. Similarity transformations are utilized to reduce the governing partial differential equations into a set of nonlinear ordinary differential equations. The reduced equations are numerically solved using Runge-Kutta-Fehlberg fourth-fifth order method along with shooting technique. The impact of several existing physical parameters on velocity, temperature, solutal and nanofluid concentration profiles are analyzed through graphs and tables in detail. It is found that, modified Dufour parameter and Dufour solutal Lewis number enhances the temperature and solutal concentration profiles respectively.