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Abstract

The paper describes an integrated laser absorption system as a potential tool for breath analysis for clinical diagnostics, online therapy monitoring and metabolic disorder control. The sensors operate basing on cavity enhanced spectroscopy and multi-pass spectroscopy supported by wavelength modulation spectroscopy. The aspects concerning selection of operational spectral range and minimization of interference are also discussed. Tests results of the constructed devices collected with reference samples of biomarkers are also presented. The obtained data provide an opportunity to analyse applicability of optoelectronic sensors in medical screening.

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Authors and Affiliations

Janusz Mikołajczyk
Tadeusz Stacewicz
Paweł Magryta
Jacek Wojtas
Zbigniew Bielecki
Dariusz Szabra
Artur Prokopiuk
Arkadiusz Tkacz
Małgorzata Panek
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Abstract

Optoelectronic technology plays an important role in medical diagnosis. In the paper a review of some optoelectronic sensors for invasive and non-invasive human health test is presented. The main attention is paid on their basic operation principle and medical usefulness. The paper presents also own research related to developing of tools for human breath analysis. Breath sample unit and three gaseous biomarkers analyzer employing laser absorption spectroscopy designed for clinical diagnostics were described. The analyzer is equipped with sensors for CO, CH4 and NO detection. The sensors operate using multi-pass spectroscopy with wavelength modulation method (MUPASS-WMS) and cavity enhanced spectroscopy (CEAS).

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Authors and Affiliations

Z. Bielecki
T. Stacewicz
J. Wojtas
J. Mikołajczyk
D. Szabra
A. Prokopiuk
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Abstract

Sensing technology has been developed for detection of gases in some environmental, industrial, medical, and scientific applications. The main tasks of these works is to enhance performance of gas sensors taking into account their different applicability and scenarios of operation. This paper presents the descriptions, comparison and recent progress in some existing gas sensing technologies. Detailed introduction to optical sensing methods is presented. In a general way, other kinds of various sensors, such as catalytic, thermal conductivity, electrochemical, semiconductor and surface acoustic wave ones, are also presented. Furthermore, this paper focuses on performance of the optical method in detecting biomarkers in the exhaled air. There are discussed some examination results of the constructed devices. The devices operated on the basis of enhanced cavity and wavelength modulation spectroscopies. The experimental data used for analyzing applicability of these different sensing technologies in medical screening. Several suggestions related to future development are also discussed.

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Authors and Affiliations

Janusz Mikołajczyk
Paweł Magryta
Tadeusz Stacewicz
Janusz Smulko
Zbigniew Bielecki
Jacek Wojtas
Dariusz Szabra
Łukasz Lentka
Artur Prokopiuk

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