Artemisinin is a powerful antimalarial drug, useful in the treatment of many diseases, includ- ing chickens coccidiosis. Its toxic effects have been well studied in humans and experimental animals, but not sufficiently in broiler chickens. Therefore, in the present study, we aimed to assess the side effects of artemisinin in chickens, by measuring the serum level of proteins and enzymes (ALT, AST, GGT, ALP, CK), by histopathological examination and by the evaluation of relative weight of organs (liver, kidney, heart). Artemisinin was administered in the standard feed for chickens in three different concentrations: 5, 50 and 500 ppm.
Each concentration of artemisinin increased the total serum proteins, gamma-globulins and the serum activity of CK and decreased the serum ALP level. The values of ALT and GGT were higher in the chickens treated with 50 and 500 ppm of artemisinin. Multifocal liver necrosis and inflammatory infiltrate were detected in the chickens that received the 50 and 500 ppm dosage of artemisinin. Minimal tubular necrosis, renal tubular epithelium vacuolation, multifocal interstitial nephritis and mild uric nephrosis were detected in chickens treated with the drug. Artemisinin administration produced no significant changes in the organs relative weight.
Artemisinin, at a concentration of 5 mg/kg of feed is well tolerated by broiler chickens, but the concentrations of 50 and 500 mg/ kg feed can produce toxic effects.
The main objective of this study was to assess the concentration of various minerals (Ca, P, Mg, Cu, Zn, Fe) in the blood of sheep, followed by biochemical analysis in order to reveal possible associations of season and breed. The study was conducted by sampling four herds: Suffolk (n=20), Merino (n=20), Lithuanian blackhead (n=20) and Charolaise (n=7). The first blood collection was conducted in April and the last one was performed in February. The highest level of Ca was estimated in Suffolk ewes, lowest (12.61%) in Merino breed; the highest Mg content was found in Lithuanian blackhead breed, lowest (5.26%) in Charolaise; highest P content was determined in Merino, lowest (24.18%) in Suffolk breed (p<0.05). Evalua- tion of the biochemical parameters during different seasons showed a possible environmental effect on the health of the animals. The difference among minerals content showed the highest level in Ca, Mg, Fe in the autumn, P - in the summer, Cu and Zn - in the winter. The lowest differences between seasons were observed in content of Mg (1.24-4.03% from total average of all seasons) and Ca (0.59-8.18%), the highest – in Cu (2.52-18.36 %) and Zn (4.33-24.33%) (p<0.05). The significance of this work is the possible use of the data in the prevention of metabolic and production diseases.
The study was conducted on 26 male, 30 days-old goats, separated from their mothers, divided into two equal groups: I - control and II - experimental, consisting of 13 animals each. All animals were fed with milk replacer, experimental group received additionally 50 g/kg body weight, additive of HMB, for 60 days. The following features were analyzed: body weight, daily increases of body weight, as well as hematological and biochemical blood features. Differences in body weight were found, between experimental and control group, after 60 days of experiment 0.57 kg (p≤0.01). The daily weight gain of experimental animals was higher in comparison with control group. Significant differences were also noted in results of hematological and biochemical blood parameters. Experimental animals showed a higher level of red blood cells as well as number of lymphocytes in comparison with the control group, (p≤0.01).Significant changes were also observed in the level of triglycerides, inorganic phosphorus and protein between both groups. The acid-base balance parameters and ionogram, showed a higher pH level (p≤0.05) HCO – act., HCO – std., BE, ctCO , O sat, K+, Cl– (p≤0.01), while the anion gap (AG) and Na+ were significantly lower in control group (p≤0.01).
The article presents personal memories of Professor Aleksander Koj’s alumni. Professor Aleksander Koj was a world-class biochemist of significant scientific achievements, a renowned authority in the field of acute-phase response regulation and acute-phase proteins. He was an excellent academic, a true Master, admired and followed by many Polish biochemists. Thrice he served as the Rector of the Jagiellonian University in Kraków. He navigated the University through a difficult time of political transformation in Poland, modernized the management system of the University and led to the commencement of the construction of the new University campus. He was the co-creator and the first Chairman of the Conference of Rectors of Academic Schools in Poland. He will be remembered as a devoted community worker aiming at strengthening the bond between the Polish community abroad and our homeland, propagating knowledge, promoting the concept of European integration, democracy and tolerance, as well as the collaboration between scientists, artists and men and women of culture. He was wise, righteous, and noble. Many had the honor of calling him their friend, and a great many saw in him a moral authority.
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