Jesuits arrived in the land of the New Kingdom of Grande (Colombia) at the beginning of the 17th century. They founded colleges in all most important towns and began the mis-sionary service among Indians, according to the scheme of so-called ‘doctrinas’, i.e. villages inhabited by autochthons. During the years 1605-1660 they worked in a few doctrines on Altiplano in the surroundings of Bogota and Tunja and on eastern slopes of the Andes. Their service was usually very effective and carried out according to the established methodology of the missionary work. They were appealing to the following rules: systematic and regular religious education, knowledge of the local languages by missionaries, development of the educational system including study of the singing and the music, practising solemn liturgy based on solid and well equipped churches. The past experience of the work in ‘doctrinas’ was used in the second half of the 17th century during the establishment of Jesuits’ reductions in Casanare, Meta and Orinoko.