Drug-abuse detection tests are becoming increasingly commonplace in patient care today and provide a rapid and effective method for identifying illicit substances. Occasionally, they may yield a positive result, indicating the presence of a substance, even though the individual has not consumed the suspected drug what sometimes can significantly impact both medical and legal decisions. The study outlines the substances that can lead to false-positive drug test results for amphetamines, cannabinoids, and benzodiazepines. The study’s findings have revealed pivotal insights for patients receiving chronic treatment and their primary care physicians. Notably, amphetamine assays appear to be most prone to cross-reactivity with other substances. The beta-blocker group of medications, confirmed by various studies to interfere with amphetamine assays, could pose a substantial challenge in drug screening given its widespread use. Efavirenz also warrants mention, as it frequently triggers positive results for both benzodiazepine and cannabinoid assays among its users. This research helps highlight new areas for further investigation and aims to guide clinicians in their daily practice, especially when interpreting questionable positive drug-abuse test results. This comprehensive review serves as a valuable resource for clinicians to navigate false-positive scenarios effectively and maintain the highest standard of patient care.

NHST (null hypothesis significance testing) is the most popular statistical paradigm in psychology. Mistakes in interpretation of its assumptions and their consequences are topic for methodological and statistical discussion for over fifty years. Article presents two problems associated with NHST that are particularly prevalent in psychology: identifying non-significant results with research failure and conducting underpowered research. They can contribute to increase in exploiting questionable research practices in order to obtain desirable, significant outcomes. Three practices: p-hacking, HARKing and selective publishing are described, along with analysis of their impact on replication crisis in psychological science.