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Telocytes in rat lungs: an essential pool of cells or not?

Anna Gil Veronika Aleksandrovych
Folia Medica Cracoviensia | 2021 | Vol. 61 | No 2 | 53-63 | DOI: 10.24425/fmc.2021.137223
Keywords lungs telocytes fibrosis rat CD34
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Abstract

Background: The histology of the lung includes a variety of cell types. Fibrosis is a universal process, occurring in the skin, intestine, heart, muscles, kidney, blood vessels, liver, and also the lungs. Telocytes are a type of cells with a wide range of properties, which were previously described in healthy and disease-affected organs of human and animal organisms.

Aim: This study aimed to identify telocytes in the lungs of rats and discuss their possible role in the development of pulmonary fibrosis.

Methods: Tissue samples were taken from a group of ten male Wistar rats. Further histological and immunohistochemical analysis was performed. Double immunolabeling for c-kit, vimentin, CD34, and PDGFRα has revealed telocytes in the lungs.

Results: In all tissue samples, telocytes have been identified (in the area of interalveolar septa, close to blood vessels, and between the airway epithelium).

Conclusion: Telocytes might be directly and indirectly (through contact with stem cells, secretomes, and reduction in number) involved in the development of pulmonary fibrosis. The heterogeneity of the telocyte population in different pathologies and their subtypes, as well as their tendency to be common stress their important role in pathological physiology.
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Bibliography

1. Schraufnagel D.E.: Electron microscopy of the lung. New York: Marcel Dekker, CRC Press; 1990.
2. Hogan B., Tata P.R.: Cellular organization and biology of the respiratory system. Nat Cell Biol. 2019. https://doi.org/10.1038/s41556-019-0357-7.
3. Evren E., Ringqvist E., Willinger T.: Origin and ontogeny of lung macrophages: from mice to humans. Immunology. 2020; 160 (2): 126–138.
4. Awad M., Gaber W., Ibrahim D.: Onset of Appearance and Potential Significance of Telocytes in the Developing Fetal Lung. Microsc Microanal. 2019; 25 (5): 1246–1256.
5. Popescu L.M., Gherghiceanu M., Suciu L.C., Manole C.G., Hinescu M.E.: Telocytes and putative stem cells in the lungs: electron microscopy, electron tomography and laser scanning microscopy. Cell Tissue Res. 2011; 345 (3): 391–403.
6. Aleksandrovych V., Pasternak A., Basta P., Sajewicz M., Walocha J.A., Gil K.: Telocytes: facts, speculations and myths (Review article). Folia Med Cracov. 2017; 57 (1): 5–22.
7. Zheng Y., Li H., Manole C.G., Sun A., Ge J., Wang X.: Telocytes in trachea and lungs. J Cell Mol Med. 2011; 15: 2262–2268.
8. Aleksandrovych V., Walocha J.A., Gil K.: Telocytes in female reproductive system (human and animal). J Cell Mol Med. 2016; 20 (6): 994–1000.
9. Díaz-Flores L., Gutiérrez R., Díaz-Flores L.J.R., Goméz M.G., Sáez F.J., Madrid J.F.: Behaviour of telocytes during physiopathological activation. Semin Cell Dev Biol. 2016; 55: 50–61.
10. Hussein M.M., Mokhtar D.M.: The roles of telocytes in lung development and angiogenesis: An immunohistochemical, ultrastructural, scanning electron microscopy and morphometrical study. Dev Biol. 2018; 443 (2): 137–152.
11. Popescu L.M., Faussone-Pellegrini M.S.: TELOCYTES — a case of serendipity: the winding way from interstitial cells of Cajal (ICC), via interstitial Cajal-like cells (ICLC) to TELOCYTES. J Cell Mol Med. 2010; 14: 729–740.
12. Ibba-Manneschi L., Rosa I., Manetti M.: Telocyte implications in human pathology: An overview. Biol. 2016; 55: 62–69.
13. Liao Z., Chen Y., Duan C., Zhu K., Huang R., Zhao H., et al.: Cardiac telocytes inhibit cardiac microvascular endothelial cell apoptosis through exosomal miRNA-21-5p-targeted cdip1 silencing to improve angiogenesis following myocardial infarction. Theranostics. 2021; 11 (1): 268–291.
14. Zhaofu L., Dongqing C.: Cardiac Telocytes in Regeneration of Myocardium After Myocardial Infarction. Adv Exp Med Biol. 2016; 913: 229–239.
15. Milia A.F., Ruffo M., Manetti M., Rosa I., Conte D., Fazi M., et al.: Telocytes in Crohn’s disease. Cell Mol Med. 2013; 17 (12): 1525–1536.
16. Ibba-Manneschi L., Rosa I., Manetti M.: Telocytes in Chronic Inflammatory and Fibrotic Diseases. Adv Exp Med Biol. 2016; 913: 51–76.
17. Wolnicki M., Aleksandrovych V., Gil A., Pasternak A., Gil K.: Relation between ureteral telocytes and the hydronephrosis development in children. Folia Med Cracov. 2019; 59 (3): 31–44.
18. Aleksandrovych V., Pasternak A., Gil K.: Telocytes in the architecture of uterine fibroids. Folia Med Cracov. 2019; 59 (4): 33–44.
19. Aleksandrovych V., Białas M., Pasternak A., Bereza T., Sajewicz M., Walocha J., et al.: Identification of uterine telocytes and their architecture in leiomyoma. Folia Med Cracov. 2018; 58 (3): 89–102.
20. Manole C.G., Gherghiceanu M., Simionescu O.J.: Telocyte dynamics in psoriasis. Cell Mol Med. 2015; 19 (7): 1504–1519.
21. Jin L., Wang Z., Qi X.: Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: Case series and a review of the literature. Medicine (Baltimore). 2018; 97 (52): e13806.
22. Leuenberger P.: [Clinical importance of non-respiratory functions of the lung]. Schweiz Med Wochenschr. 1983; 113 (29): 1006–1010.
23. Wittmann J.: [Respiratory and non-respiratory functions of the lung]. Tierarztl Prax Suppl. 1987; 2: 33–36.
24. Aleksandrovych V., Kurnik-Łucka M., Bereza T., Białas M., Pasternak A., Cretoiu D., Walocha J.A., Gil K.: The Autonomic Innervation and Uterine Telocyte Interplay in Leiomyoma Formation. Cell Transplant. 2019; 28: 619–629.
25. Song D., Cretoiu D., Cretoiu S.M., Wang X.: Telocytes and lung disease. Histol Histopathol. 2016; 31 (12): 1303–1314.
26. Shi L., Dong N., Chen C., Wang X.: Potential roles of telocytes in lung diseases. Semin Cell Dev Biol. 2016; 55: 31–39.
27. Ciechanowicz A.: Stem Cells in Lungs. Adv Exp Med Biol. 2019; 1201: 261–274.
28. Rokicki W., Rokicki M., Wojtacha J., Dżeljijli A.: The role and importance of club cells (Clara cells) in the pathogenesis of some respiratory diseases. Kardiochir Torakochirurgia Pol. 2016; 13 (1): 26–30.
29. Ibba-Manneschi L., Rosa I., Manetti M.: Telocytes in Chronic Inflammatory and Fibrotic Diseases. Adv Exp Med Biol. 2016; 913: 51–76.
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Authors and Affiliations

Anna Gil
1
Veronika Aleksandrovych
1
  1. Department of Pathophysiology, Jagiellonian University Medical College, Kraków, Poland

The disease and an immediate cause of death of Frederic Chopin

Michał Witt
Nauka | 2021 | No 2 | 181-190 | DOI: 10.24425/nauka.2021.136322
Keywords Frederic Chopin cystic fibrosis heart pericarditis tuberculosis
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Abstract

Based on a visual analysis of the heart of Frederic Chopin performed in 2014 and described above, it can be stated with high probability that the composer suffered from a long lasting tuberculosis as a primary disease, which was the cause of progressive deterioration of his physical condition and numerous symptoms mainly from the respiratory tract. Tuberculous pericarditis rapidly progressing within a rather short period of time, a relatively rare complication of diffuse tuberculosis, might have been an immediate cause of death. This would aptly coincide with a startling opinion that in an autopsy picture the composer’s heart had been more affected by the disease than the lungs.
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Authors and Affiliations

Michał Witt
1
  1. Instytut Genetyki Człowieka PAN, Poznań

Sex steroid hormone receptors of telocytes — potential key role in leiomyoma development

Veronika Aleksandrovych Anna Gil Anna Wrona
Folia Medica Cracoviensia | 2020 | Vol. 60 | No 2 | 81-95 | DOI: 10.24425/fmc.2020.135015
Keywords leiomyoma extracellular matrix telocytes CD34 estrogen progesterone fibrosis
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Abstract

Background: Uterine leiomyoma is the most widespread benign tumor affecting women of childbearing age. There are still gaps in the understanding of its pathogenesis. Telocytes are unique cells found in more than 50 different locations inside the human body. The functional relationship between cells could clarify the pathogenesis of leiomyomata. Examination of membrane receptors on telocytes could explain their role in fibrosis, oxidative stress, and myometrial contractility.

Aim: This research was conducted to assess the density of telocytes in terms of their putative role in leiomyoma formation by focusing on their correlation with the expression of estrogen and progesterone receptors.

Methods: For gross evaluation of uterine tissue samples from leiomyoma, routine histology of adjacent and unaffected myometrium was performed. Immunohistochemical analysis of c-kit, tryptase, CD34, PDGFRα (telocyte-specific), and ER and PRs (estrogen and progesterone receptors) was performed to examine uterine telocytes and the expression of sex steroid receptors.

Results: The decline in telocyte density in leiomyoma foci was correlated with high progesterone expression and low estrogen receptor expression. The unchanged myometrium showed the opposite correlation and balance between both steroid hormone receptors. The difference in sex steroid receptor expression is correlated with the density of uterine telocytes, which emphasizes their conductor function.

Conclusions: A reduction in telocyte density and the changes in examined marker expression demon-strate the involvement of telocytes in local homeostasis. The expression of membrane receptors explicitly indicates their functional potential in the human myometrium, focusing attention on contractility and local homeostasis.

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Authors and Affiliations

Veronika Aleksandrovych
Anna Gil
Anna Wrona

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