Transport properties of bronchial mucus are investigated by two-stage experimental approach focused on: (a) rheological properties and (b) mass transfer rate through the stagnant layer of solutions of mucus components (mucine, DNA, proteins) and simulated multi-component mucus. Studies were done using thermostated horizontal diffusion cells with sodium cromoglycate and carminic acid as transferred solutes. Rheological properties of tested liquids was studied by a rotational viscometer and a cone-plate rheometer (dynamic method). First part of the studies demonstrated that inter-molecular interactions in these complex liquids influence both rheological and permeability characteristics. Transfer rate is governed not only by mucus composition and concentration but also by hydrophobic/hydrophilic properties of transported molecules. Second part was focused on the properties of such a layer in presence of selected nanostructured particles (different nanoclays and graphene oxide) which may be present in lungs after inhalation. It was shown that most of such particles increase visco-elasticity of the mucus and reduce the rate of mass transfer of model drugs. Measured effects may have adverse impact on health, since they will reduce mucociliary clearance in vivo and slow down drug penetration to the bronchial epithelium during inhalation therapy.
The aim of this study was to determine the influence of feed on the pharmacokinetics of flumequine (FLU) administered to broiler chickens as follows: directly into the crop (10 mg/kg of BW) of fasted (group I/control) and non-fasted chickens (group II), or administered continu- ously with drinking water (1 g/L for 72 h) and with unlimited access to feed (group III). Plasma concentration of FLU was determined by high-performance liquid chromatography with fluo- rescence detection. In group II, a significant decrease in the maximum concentration (Cmax = 2.13±0.7 μg/mL) and the area under the concentration curve from zero to infinity (AUC0→∞ = 7.47±2.41 μg·h/mL) was noted as compared to the control group (Cmax = 4.11±1.68 μg/mL and AUC0→∞ = 18.17±6.85 μg·h/mL, respectively). In group III, the decrease in AUC was signifi- cant only in the first 3 hours (AUC0→3 = 5.02±1.34 μg·h/mL) as compared to the control group (AUC0→3 = 7.79±3.29 μg·h/mL). The results indicate that feed reduced the bioavailability of FLU from the gastrointestinal tract by at least 50% after the administration of a single oral dose. However, continuous administration of FLU with drinking water could compensate for the feed-induced decrease in absorption after single oral dose.
Red basil (Ocimum basilicum L.) cv. Red Rubin was cultivated in model pot experiment in the soil amended by arsenic, cadmium and lead solutions in stepwise concentrations representing the soil concentration levels of former mining area in the vicinity of Příbram, Czech Republic. The element levels added to the soil reached up to 40 mg Cd, 100 mg As, and 2000 mg Pb per kg of soil. Moreover, essential macro-and microelements as well as cyanidine contents were investigated to assess their potential interactions with the risk elements. The extractable element portions in soils determined at the end of vegetation period differed according to the individual elements. Whereas the plant-available (extractable with 0.11M CH3COOH) content of Cd represented 70-100% of the added Cd, the mobile portion of Pb did not exceed 1%. The risk element content in plants reflected the increasing element contents in soil. The dominant element portions remained in plant roots indicating the limited translocation ability of risk elements to the aboveground biomass of this plant species. Although the risk element contents in amended plants significantly increased, no visible symptoms of phytotoxicity occurred. However, the effect of enhanced risk element contents on the essential element uptake was assessed. Considering inter-element relationships, elevated sulphur levels were seen in amended plants, indicating its possible role of phytochelatin synthesis in the plants. Moreover, the molybdenum contents in plant biomass dropped down with increasing risk element uptake by plants confirming As-Mo and Cd-Mo antagonism. The increasing content of cyanidine in the plant biomass confirmed possible role of anthocyanins in detoxification mechanism of risk element contaminated plants and suggested the importance of anthocyanin pigments for risk element tolerance of plants growing in contaminated areas.
The pesticide persistence, in particular in soils, often significantly exceeding the declarations of their manufacturers is surprising. There are many publications devoted to the explanation of this phenomenon in the field literature, but the diverse research methodologies used may lead to the ambiguous conclusions. On the basis of the collected literature, the attempt was made to systematize the available information on the interactions of commonly used groups of pesticides with individual soil components. The complex mechanisms of interactions between pesticides and soil based on van der Waals forces, ionic and covalent bonding, ligand exchange and charge transfer complexes formation were demonstrated. It was also proved that the nature of interactions is strictly dependent on the structure of the pesticide molecule. The conclusion of the review may contribute to the choice of plant protection products that, in addition to their effectiveness, are as little ballast for the environment as possible.
Despite many years of research, we have yet to discover all the myriad ways various components of the climate interact. For instance, it looks likely that the circulation of oceanic waters has a much broader impact than previously thought.
We consider fiscal and monetary policy interactions in a monetary unionunder monetary leadership, when the common central bank is concerned with theaverage fiscal stance of the union. We use a static two-country monetary unionmodel to investigate the policy-mix problem under different regimes of non-cooperation, cooperation, and enforced cooperation among fiscal authorities.We find that fiscal policy is unambiguously countercyclical, a feature that ismore pronounced under fiscal policy cooperation. Monetary policy can be eithercountercyclical or procyclical. A central bank concerned about the aggregatefiscal stance is effective in stabilizing output and central budget, but at theexpense of inflation stabilization.
Development of new or upgrading of existing airplanes requires many different analyses, e.g., thermal, aerodynamical, structural, and safety. Similar studies were performed during re-design of two small aircrafts, which were equipped with new turboprop engines. In this paper thermo-fluid analyses of interactions of new propulsion systems with selected elements of airplane skin were carried out. Commercial software based numerical models were developed. Analyses of heat and fluid flow in the engine bay and nacelle of a single-engine airplane with a power unit in the front part of the fuselage were performed in the first stage. Subsequently, numerical simulations of thermal interactions between the hot exhaust gases, which leave the exhaust system close to the front landing gear, and the bottom part of the fuselage were investigated. Similar studies were carried out for the twin-engine airplane with power units mounted on the wings. In this case thermal interactions between the hot exhaust gases, which were flowing out below the wings, and the wing covers and flaps were studied. Simulations were carried out for different airplane configurations and operating conditions. The aim of these studies was to check if for the assumed airplane skin materials and the initially proposed airplane geometries, the cover destruction due to high temperature is likely. The results of the simulations were used to recommend some modifications of constructions of the considered airplanes.
To achieve better precision of features generated using the micro-electrical discharge machining (micro-EDM), there is a necessity to minimize the wear of the tool electrode, because a change in the dimensions of the electrode is reflected directly or indirectly on the feature. This paper presents a novel modeling and analysis approach of the tool wear in micro-EDM using a systematic statistical method exemplifying the influences of capacitance, feed rate and voltage on the tool wear ratio. The association between tool wear ratio and the input factors is comprehended by using main effect plots, interaction effects and regression analysis. A maximum variation of four-fold in the tool wear ratio have been observed which indicated that the tool wear ratio varies significantly over the trials. As the capacitance increases from 1 to 10 nF, the increase in tool wear ratio is by 33%. An increase in voltage as well as capacitance would lead to an increase in the number of charged particles, the number of collisions among them, which further enhances the transfer of the proportion of heat energy to the tool surface. Furthermore, to model the tool wear phenomenon, a egression relationship between tool wear ratio and the process inputs has been developed.
Neighbouring as a type of social interchange and multi-dimensional social phenomenon is of funda-mental importance in the social sciences and problems associated with intercultural and interethnic neighbouring are currently on the increase. Contemporary migration processes and ethnic diversity in Poland are relatively new issues that are reflected in the experiences of both migrants and representa-tives of the host society. The aim of this article is to analyse intercultural neighbourly contacts be-tween Poles and migrants in Warsaw in the context of Erving Goffman’s sociology of interaction. These contacts and the social processes they involve are of great importance when it comes to mi-grants’ integration in their new place of residence. The article considers how glances, gestures and behaviours are interpreted, leading to the formation of specific opinions and attitudes between mi-grants and Poles. Both ‘unfocused’ and ‘focused’ interactions are analysed, with an emphasis on ex-pectations and definitions of tactful behaviour in intercultural neighbourly encounters and the concept of ‘polite indifference.’ Conclusions are based on semi-structured interviews conducted with Poles and migrants from Vietnam, Turkey and African countries living in Warsaw, Poland.
A study of the Quran makes it clear, that the New and Old Testament traditions are manifest in various forms in the sacred book of Muslims. This paper presents the phenomenon of these biblical borrowings, giving the references in the Quran to the biblical persons and main themes. One finds many of the Old and New Testament stories of the prophets sometimes in precise forms where the Quranic records are relative identical with the Biblical versions. On other fragments the Quranic narra- tives contain elements of Biblical traditions mixed with folklore and fables extracted from the Talmud and in some cases (such as the story of Abraham and the idols) the sources are entirely Midrashic-Haggadic or Apocryphal. It is worth to be pointed out that the influence of orthodox Christianity on the Quran was slight but apocryphal and heretical Christian legends are clearly visible in the various Quranic fragments. Probably it is a result of Muhammad’s journeys between Syria, Hijaz, and yemen.
Scholars have adopted a number of different theories explaining the phenomenon of the biblical borrowings found in the Quran. For example it is said about Muham- mad’s dependence upon Jewish teachers and thus an overarching Jewish influence on Islam. It is generally admitted that Muhammad had opportunity to come into contact with yemenite, Abyssinian, Ghassanite, and Syrian Christians, especially heretic.
Analyzes of the Quran in the light of parallel passages in the Bible, Talmud and Apocrypha permits us to formulate an idea that early Islamic revelations were com- pilation of Muhammad inspiration with repetition of information coming to his ears, some of it Biblical and true to history, the rest predominantly mythical and fictitious. This thesis is not accepted by Muslim scholars, who maintain that the Qur’an is the divine word of God without any interpolation.
The category of expectation constitutes an important element of reflection in many scientific disciplines focusing on man. it is treated in both the categories of expectations inscribed in large social projects (e.g. of utopian nature) and individual expectations which build human daily routine. The article is divided into two parts. in the first, the issues of interpersonal expectations, analysed in the perspective of social psychology and sociology, will be undertaken. what will be explored here are the problems of defining the notion of expectation and the problems of expectations at school, which will be exemplified by the pygmalion effect. The first part is completed with some considerations on the meaning of expectation in sociology, the role of expectations in interaction, and the relations between expecting and social order.
In the second part, the author focuses on the issues of expectations inscribed in utopian projects (“great expectations”). pedagogical utopias and relations between utopias and popularization of normative (formal) or informal pedagogies are subjected to analysis. The author makes here some references to the concept of post-materialistic society, attempting to elicit relations between this type of society and popularization of nonformal pedagogies.
In this paper, effects of non-Fourier thermal wave interactions in a thin film have been investigated. The non-Fourier, hyperbolic heat conduction equation is solved, using finite difference method with an implicit scheme. Calculations have been carried out for three geometrical configurations with various film thicknesses. The boundary condition of a symmetrical temperature step-change on both sides has been used. Time history for the temperature distribution for each investigated case is presented. Processes of thermal wave propagation, temperature peak build-up and reverse wave front creation have been described. It has been shown that (i) significant temperature overshoot can appear in the film subjected to symmetric thermal load (which can be potentially dangerous for reallife application), and (ii) effect of temperature amplification decreases with increased film thickness.
The diversity of wave modes in the magnetic gas gives rise to a wide variety of nonlinear phenomena associated with these modes. We focus on the planar fast and slow magnetosound waves in the geometry of a flow where the wave vector forms an arbitrary angle θ with the equilibrium straight magnetic field. Nonlinear distortions of a modulated signal in the magnetic gas are considered and compared to that in unmagnetised gas. The case of acoustical activity of a plasma is included into consideration. The resonant three-wave non-collinear interactions are also discussed. The results depend on the degree of non-adiabaticity of a flow, θ, and plasma-β.
The green peach aphid, Myzus persicae (Sulzer), is a polyphagous and holocyclic aphid which significantly damages agricultural crops. In the current study, the effects of micronutrients on some secondary metabolites of bell pepper (Capsicum annum L.) leaves and their subsequent influence on the life table parameters of M. persicae were investigated under greenhouse conditions. The flavonoid content in bell pepper leaves significantly changed following micronutrient treatments in the wavelength of 270 nm while there were no significant differences in the wavelengths 300 and 330 nm. The highest anthocyanin content was recorded after Fe treatment (3.811 mg ⋅ ml–1) while the total phenolic content in the bell pepper leaves increased after Mn (541.2 mg ⋅ ml–1) treatment compared to Fe (254.5 mg ⋅ ml–1) and control (216.33 mg ⋅ ml–1), respectively. The highest values of intrinsic (r) and finite rates of population increase (λ) of M. persicae were gained with Zn (0.320 and 1.377 day–1, respectively) treatment although the highest and the lowest values of the mean generation time (T) were found with Fe and Zn (14.07 and 12.63 days, respectively) treatments, respectively. Our findings suggest that Mn, more than Zn micronutrients, decreased ecological fitness of green peach aphid and may help enhance the efficiency of pest control techniques.