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Abstract

Primiparous and multiparous lactating crossbred dairy cows with a mature corpus luteum and a follicle with >10 mm in diameter were treated with cloprostenol. Those cows that showed oestrus within 5 days after treatment were inseminated (Group P). The other cows (Group PG) were treated with GnRH 2 days after cloprostenol treatment and timed artificial insemination (AI) was performed on the consecutive day, or were inseminated (Group G) after detected oestrus and treated with GnRH immediately after AI. The control cows (Group C) after detected oestrus were only inseminated. All of the AIs using frozen semen were done between 6 and 7 a.m. while the ultrasonographic examinations after AI were performed between 4 to 6 p.m. The ovaries of each cow were scanned by means of transrectal ultrasonography from the day of AI until ovulation. Daily blood samples were collected for progesterone measurements. The ovulation and preg- nancy rates among the groups changed between 84.6% and 95.5%, as well as 44.4% and 60%, respectively, however the differences were not statistically significant.

All the cows were evaluated according to date of ovulation after AI and the pregnancy rate was 55.4% (Group 1: ovulation occurred between AI and 9-11 h after AI), 54.5% (Group 2: ovulation occurred between 9-11 h and 33-35 h after AI) and 35.5% (Group 3: ovulation occurred between 33-35 h and 57-59 h after AI), respectively. There was a trend (P=0.087) for 2.2 greater odds of staying open among cows inseminated between 33 to 35 h and 57 to 59 h before ovulation compared to cows inseminated within 9 to 11 h before ovulation. If ovulation occurred before AI, the pregnancy rate was only 22.2%, therefore determination of optimal time for AI is of great importance.

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Authors and Affiliations

A. Répási
Z. Szelényi
N. Melo De Sousa
J.F. Beckers
K. Nagy
O. Szenci
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Abstract

Dieldrin and DDE are environmental metabolites of the organochlorine pesticides aldrin and DDT, respectively. During pregnancy, these chemicals can quickly infiltrate through the placental barrier, accumulate in amniotic fluid and fetus, and act as endocrine disruptors (EDs). The aim of this study was to investigate the effect of DDE and dieldrin and their parental substances at concentrations of 1 and 10 ng/ml on secretion of PGE2 and PGF2α from bovine endometrial explants (120-150 and 151-180 days of pregnancy) after 24 hr of incubation with EDs. The mRNA expression of COX2, PGES and PGFS and the concentrations of PGE2 and PGF2α were measured. EDs did not affect (p>0.05) COX2 gene expression, but DDT and DDE decreased (p<0.05) PGES expression and PGE2 secretion in the explants from 120-150 days of pregnancy. Depending on the dose, DDT and DDE increased (p<0.05) PGFS expression and PGF2α secretion from the explants from 120-150 days and decreased PGF2α secretion (p<0.05) from the explants from 151-180 days of pregnancy. Aldrin and dieldrin decreased (p<0.05) PGFS expression and PGF2α secretion from all explants. In summary, EDs disrupt the secretion of PGE2 and PGF2α by influencing the gene expression of PGES and PGFS.
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Bibliography

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Authors and Affiliations

J. Mlynarczuk
1
M.H. Wrobel
1
K. Dobrzyn
1

  1. Institute of Animal Reproduction and Food Research Polish Academy of Sciences, Department of Physiology and Toxicology of Reproduction, Tuwima 10, 10-747 Olsztyn, Poland
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Abstract

I n t r o d u c t i o n: Induction of labor is an intervention in the obstetrics, which aim is to achieve cervical ripening and stimulate contractions of uterus before beginning of labor. The purpose of our study was to evaluate efficacy of combinations of vaginal misoprostol, intracervical dinoprostone and Foley catheter at term with regard to mode of delivery and rate of emergency C-sections due to birth asphyxia.

Ma t e r i a l a n d Me t h o d s: 403 singleton pregnant women, who underwent pharmacological labor induction at term, were reviewed. Patients were divided into 2 main cohorts due to beginning of induction algorithm: vaginal misoprostol (66) or intracervical dinoprostone (337) consisting of 3 subgroups — PGE2 alone (184), PGE2+Foley catheter (125), PGE2+Foley catheter+PGE1 (28).

R e s u l t s: Comparison of maternal age, presence of cervical dilation and parity revealed no major differences between cohorts. Eff ectiveness of labor induction with misoprostol, dinoprostone and dinoprostone followed by Foley catheter were respectively 90.9%, 51.3%, and 82.8%. Addition of PGE1 was effective in 83% of patients with negative response to PGE2 followed by Foley catheter. There was no statistically significant diff erence in rate of C-sections between dinoprostone and misoprostol cohorts, C-section due to birth asphyxia were insignificantly more frequent in PGE1 than in PGE2 cohort. Efficacy in the subgroup administered only dinoprostone was significantly higher in 40th than in 41th (p = 0.016).

C o n c l u s i o n s: Intracervical dinoprostone seems to be safer, but less effective in labor induction than vaginal misoprostol. Following PGE2 by other methods increased efficacy of induction in this cohort.

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Authors and Affiliations

Anna Modrzyńska
Małgorzata Radoń-Pokracka
Magdalena Płonka
Beata Adrianowicz
Gabriela Wilczyńska
Magdalena Nowak
Hubert Huras
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Abstract

The aim of this study was to evaluate the efficacy of the Ovsynch protocol in the treatment of post-service subestrus in individual dairy cows compared to a single administration of PGF2α. The study was performed on 517 Polish Friesian Holstein cows with post-service anestrus over four years in 3 dairy herds under a herd health program. Cows (n=240) diagnosed ultrasonographically as non-pregnant and with a mature corpus were treated with a single PGF2α administration and inseminated at detected estrus. Cows without corpus (n=277) were treated with the Ovsynch protocol. The estrus detection rate after PGF2α administration, percentages of cows pregnant after the treatment and at day 260, intervals from parturition to treatment and from treatment to conception and pregnancy loss rates were calculated. The overall percentage of cows pregnant after treatment did not differ between animals treated with the Ovsynch protocol and with PGF2α (38.9% vs. 42.5%; p>0.05). In herd A the percentage of cows pregnant after treatment was significantly lower (p<0.05) for the Ovsynch group than for the PGF2α group (30.2% vs. 61.2%). In contrast, in herd C the percentage of cows pregnant after treatment was significantly higher (p<0.05) in the Ovsych group than in the PGF2α group (39.6% vs. 28.8%). The overall estrus detection rate after administration of PGF2α was 59.6%. However, it was significantly lower (p<0.05) in herd C (44.7%) than in herds A (79.6%) and B (76.3%). The overall pregnancy loss rate ranged from 5.1% to 13.3% and did not differ significantly between herds and treatment groups (p>0.05). In conclusion, Ovsynch protocol can be a useful alternative for treatment of post-service suboestrus in individual cows in dairy herds with insufficient oestrus detection.
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Authors and Affiliations

W. Barański
1
A. Nowicki
1
S. Zduńczyk
1

  1. Department of Animal Reproduction with Clinic, University of Warmia and Mazury, ul. Oczapowskiego 14, 10-719 Olsztyn, Poland

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