@ARTICLE{Feng_F._Effect_2018, author={Feng, F. and Ma, W.W. and Luo, H.X. and Guan, C.P. and Zhou, X.Z.}, volume={vol. 21}, number={No 2}, journal={Polish Journal of Veterinary Sciences}, pages={409-413}, howpublished={online}, year={2018}, publisher={Polish Academy of Sciences Committee of Veterinary Sciences}, publisher={University of Warmia and Mazury in Olsztyn}, abstract={Taking bacterial virulence factors as targets is a new therapy for treating host bacterial infection. The aim of this study was to investigate the effect of matrine on α-hemolysin production of Staphylococcus aureus (S. aureus) and reducing the damage to bovine mammary epithelial cells (BMECs) induced by S. aureus α-hemolysin. Subinhibitory concentrations of matrine decreased the production of α-hemolysin in none dose-dependent manner and matrine exhibited a protective effect on S. aureus-induced BMECs injury. The results indicated that the structure of matrine may potentially be used as a basic structure for development of drugs aimed at curing and preventing dairy bovine mastitis.}, type={Artykuły / Articles}, title={Effect of matrine on reducing damage to bovine mammary epithelial cells induced by Staphylococcus aureus alpha-hemolysin}, URL={http://journals.pan.pl/Content/106882/PDF/23.pdf}, doi={10.24425/122610}, keywords={α-hemolysin, BMECs, matrine, cell damage}, }