@ARTICLE{Yildizhan_E._Protective_2023,
 author={Yildizhan, E. and Ozesmer, H. and Inan, M.M. and Tatli, F. and Rencber, M. and Akbas, A. and Kamar, M. and Gündüz, E. and Baksi, N. and Ulger, B.V. and Akkuş, M. and Kaydu, A.},
 volume={vol. 26},
 number={No 3},
 journal={Polish Journal of Veterinary Sciences},
 pages={343-347},
 howpublished={online},
 year={2023},
 publisher={Polish Academy of Sciences Committee of Veterinary Sciences},
 publisher={University of Warmia and Mazury in Olsztyn},
 abstract={The aim of this study is to determine the protective efficacy of anise in cerebral ischemia and reperfusion injury in rats. In this study, 28 Wistar Albino rats, weighing 250-300 grams (g), were used. Four groups were formed with 7 rats in each group. Group 1 (n=7): Control group, Group 2 (n=7): Anise group, 5 mL/kg/day of anise aqueous extract prepared according to Gamberini’s protocol was given orally by gavage for 30 days. Group 3 (n=7): Cerebral ischemia reperfusion (CIR) group, at the beginning of the experiment, 30 minutes of cerebral ischemia and 1 hour of reperfusion were induced and the animals were sacrificed by exanguination. Group 4 (n=7): Anise+ CIR group, After administering 30 days of anise’s aqueous extract, CIR was induced and the study was terminated. TOS values of the Anise+ CIR group was significantly lower than that of the CIR group (p<0.05). Il-6 and TNF-α values of the CIR group were significantly higher than the Anise+ CIR group (p<0,05). Our study revealed that anise ameliorates oxidative damage and inflammation due to cerebral ischemia/reperfusion, by reducing the levels of inflammatory cytokines (TNF-α, Il-6).},
 type={Article},
 title={Protective effects of anise in prevention of cerebral ischemia reperfusion injury in rats},
 URL={http://journals.pan.pl/Content/128500/PDF/2%20_%20Yildizhan.pdf},
 doi={10.24425/pjvs.2023.145038},
 keywords={Anise, cerebral ischemia reperfusion, oxidative stress, inflammation},
}