TY - JOUR N2 - Oxidative stress (OxS) has been implicated in the pathogenesis of Crohn’s disease (CD). The aim of this study was to examine whether nonenzymatic antioxidants are associated with active CD, by using the FRAP and GSH assay in plasma. Additionally, we measured bilirubin and albumin levels as two individual components of the plasma antioxidant system. A total of 55 patients with established CD, 30 with active CD and 25 with inactive disease, and 25 healthy individuals were prospectively enrolled in this study. We evaluated CD activity index, BMI and blood morphology, platelet count, serum CRP level, and bochemical parameters of OxS: ferric reducing ability of plasma (FRAP), reduced glutathione (GSH) in plasma and bilirubin and albumin levels in serum. Plasma FRAP and GSH concentrations were decreased in both CD groups compared to controls and negatively correlated with CDAI values (FRAP: r = –0.572, p = 0.003; GSH: r = –0.761, p = 0.001), CRP and platelet count. Bilirubin and albumin levels were lower in the serum of active CD patients than inactive CD patients and controls and negatively correlated with the CD activity index (r = –0328, p = 0.036, r = –0.518, p = 0.002) and CRP (r = –0.433, p = 0.002). The decreased FRAP and GSH levels in plasma and bilirubin and albumin levels in serum of patients with active CD compared to inactive CD and controls underlines the importance of OxS in the pathophysiology and activity of CD. L1 - http://journals.pan.pl/Content/108798/PDF/FMC%202-18%2010-Szczeklik.pdf L2 - http://journals.pan.pl/Content/108798 PY - 2018 IS - No 2 EP - 130 DO - 10.24425/fmc.2018.124663 KW - Crohn’s disease KW - oxidative stress KW - FRAP assay KW - glutathione KW - bilirubin KW - albumin A1 - Szczeklik, Katarzyna A1 - Krzyściak, Wirginia A1 - Cibor, Dorota A1 - Kozioł, Kamil A1 - Pocztar, Halina A1 - Pytko-Polończyk, Jolanta A1 - Mach, Tomasz A1 - Owczarek, Danuta PB - Oddział PAN w Krakowie; Uniwersytet Jagielloński – Collegium Medicum VL - vol. 58 DA - 2018.06.30 T1 - Evaluation of plasma concentrations of selected antioxidant parameters in patients with active Crohn’s disease SP - 119 UR - http://journals.pan.pl/dlibra/publication/edition/108798 T2 - Folia Medica Cracoviensia ER -