TY - JOUR N2 - The aim of the study was to compare anaesthesia protocol utilizing combination ketamine/ medetomidine with epidural lidocaine or morphine to orthopaedic surgery in rabbits. All rabbits received intramuscularly medetomidine (0.5 mg/kg) and ketamine (20 mg/kg). In group L (n=13) epidural injection was performed with lidocaine (3 mg/kg) and in group M (n=13) with morphine (0.1 mg/kg) diluted with sterile saline to 0.6 ml. Rabbits underwent bilateral mosaicplasty surgery. Heart rate (HR), systolic (SBP), diastolic (DBP) and mean arterial blood pressure (MAP), arte- rial oxygen saturation (SpO2) and respiratory rate (RR) were measured every 5 minute during surgical procedure. Duration of sensory blockade was measured based on toe pinch reflex and recorded. Hemodynamic parameters were comparable at baseline in both groups. We did not observe significant differences in HR, RR, SBP, DBP, MAP between group L and M. Intragroup statistical analysis revealed differences at different time points in group M in terms of HR, SBP, DBP, MAP. In rabbits in group M blood pressure dropped while HR increased over time. In both groups a decrease in SpO2 was observed. Mean duration of loss of the toe pinch reflex was similar between group L and M, and amounted to 72.79±34.48 and 82.80±17.85 minutes, respectively. L1 - http://journals.pan.pl/Content/109596/PDF/05.pdf L2 - http://journals.pan.pl/Content/109596 PY - 2019 IS - No 1 EP - 35 DO - 10.24425/pjvs.2018.125604 KW - epidural anesthesia KW - intraoperative pain KW - lidocaine KW - morphine A1 - Antończyk, A. A1 - Liszka, B. A1 - Skrzypczak, P. A1 - Kiełbowicz, Z. PB - Polish Academy of Sciences Committee of Veterinary Sciences PB - University of Warmia and Mazury in Olsztyn VL - vol.22 DA - 2019.04.04 T1 - Comparison of analgesia provided by lidocaine or morphine delivered epidurally in rabbits undergoing hindlimb orthopedic surgery SP - 31 UR - http://journals.pan.pl/dlibra/publication/edition/109596 T2 - Polish Journal of Veterinary Sciences ER -