TY - JOUR N2 - Correct diagnosis and appropriate selection of pharmacotherapy will not upgrade patient’s health if the drug is not available in the pharmacy. Pharmaceutical supply chain breakdown may occur due to epidemiological or political reasons. Then, the finished drug form factories located in Poland will not secure the drug supply. Thus, cooperation of the scientific community with the pharmaceutical and chemical industries is necessary to boost the domestic manufacturing of active pharmaceutical substances and substrates. Due to number of substances needed, the scale of national demand and the investments, the problem needs to be solved at European level. The Pharmaceutical Strategy for Europe is an important guidance in this regard. The aim of our paper is to review the current state, indicate solutions and initiate a discussion on the development of the synthesis of active pharmaceutical substances in Poland. We focused on small-molecular compounds, the national perspective and the relationship between the synthesis of active substances and protection of the natural environment. Point actions for investments in infrastructure as well as research and development are not enough. Thus, we propose to create a system supporting synthesis of active pharmaceutical substances in Poland. L1 - http://journals.pan.pl/Content/119203/PDF/N%23321-03-Strategia-farmaceutyczna.pdf L2 - http://journals.pan.pl/Content/119203 PY - 2021 IS - No 3 EP - 66 DO - 10.24425/nauka.2021.136326 KW - pharmacy KW - chemical synthesis technology KW - European Union KW - active pharmaceutical ingredients (API) KW - drug supply chain security KW - green chemistry A1 - Grynkiewicz, Grzegorz A1 - Jachowicz, Renata A1 - Kopeć, Krzysztof A1 - Krause, Anna A1 - Kuźmierkiewicz, Wojciech A1 - Lulek, Janina A1 - Maciejewska, Beata A1 - Moszczyński-Petkowski, Rafał A1 - Rachoń, Janusz A1 - Rudzki, Piotr J. PB - Biuro Upowszechniania i Promocji Nauki PAN DA - 2021.07.22 T1 - „Pharmaceutical Strategy for Europe”: synthesis of active pharmaceutical ingredients as a Polish brand? SP - 47 UR - http://journals.pan.pl/dlibra/publication/edition/119203 T2 - Nauka ER -