Zearalenone-induced changes in the lymphoid tissue and mucosal nerve fibers in the porcine ileum

Journal title

Polish Journal of Veterinary Sciences




No 2


Divisions of PAS

Nauki Biologiczne i Rolnicze


Polish Academy of Sciences Committee of Veterinary Sciences ; University of Warmia and Mazury in Olsztyn


2015[2015.01.01 AD - 2015.12.31 AD]


DOI: 10.1515/pjvs-2015-0046 ; ISSN 1505-1773


Marin (2011), Effects of zearalenone and its derivatives on porcine immune response, Toxicol In Vitro, 25, 1981, ; Laurenzi (1990), The neuropeptide substance P stimulates production of interleukin in human blood monocytes : activated cells are preferentially influenced by the neuropeptide, Scand J Immunol, 31, 529, ; Levite (1998), Neuropeptides , via specific receptors , regulate T cell adhesion to fibronectin, J Immunol, 160. ; Yiangou (1990), Effects of prepro - vasoactive intestinal peptide - derived peptides on the murine immune response, J Neuroimmunol, 29, 65, ; Van Ginderachter (2006), Classical and alternative activation of mononuclear phagocytes : picking the best of both worlds for tumor promotion, Immunobiology, 211. ; Kincy (1997), Substance P - induced IL - production by murine macrophages, J Immunol, 158. ; Marriott (2000), Substance P activates NF - kappa B independent of elevations in intracellular calcium in murine macrophages and dendritic cells, J Neuroimmunol, 102, 163, ; Gonkowski (2012), Changes in pituitary adenylate cyclase - activating Peptide - like immunoreactive nervous structures in the porcine descending colon during selected pathological processes, J Mol Neurosci, 27, 777, ; Hus (2010), The role of Th cells in anti - cancer immunity, Postepy Med Online, 17, 244. ; Fitzpatrick (1989), Measurement of the relative binding affinity of zearalenone , alfa - zearalenol and beta - zearalenol for uterine and oviduct estrogen receptors in swine , rats and chickens : an indicator of estrogenic potencies, Comp Biochem Physiol, 691. ; Vasina (2006), Enteric neuroplasticity evoked by inflammation, Auton Neurosci, 126. ; Gonkowski (2003), The influence of experimental Bacteroides fragilis infection on substance P and somatostatin - immunoreactive neural elements in the porcine ascending colon a preliminary report, Folia, 455. ; Mantyh (1996), Substance P activation of enteric neurons in response to intraluminal Clostridium difficile toxin A in the rat ileum, Gastroenterology, 111, 1272, ; Lakomy (2009), Changes in the content of neuropeptides in intestinal lymph nodes of pigs suffering from experimentalBrachyspira hyodysenteriaeinfection, Vet Med, 54, 315. ; Marin (2013), Effects of zearalenone on oxidative stress and inflammation in weanling piglets, Food Chem Toxicol, 58, 408, ; Delgado (2001), Cutting edge : is vasoactive intestinal peptide a type cytokine, J Immunol, 166. ; Kulkarni (1999), Catecholaminergic , cholinergic and peptidergic innervation of gut - associated lymphoid tissue in porcine jejunum and ileum, Cell Tissue Res, 298. ; Kaleczyc (2010), Characterization of autonomic nerve markers and lymphocyte subsets in the ileal Peyer s patch of pigs infected experimentally with Brachyspira hyodysenteriae, J Comp Pathol, 143. ; Delgado (1996), Differential expression of vasoactive intestinal peptide receptors and VIP - mRNA in murine lymphocytes, J Neuroimmunol, 68, 27, ; Vulchanova (2007), Anatomical evidence for enteric neuroimmune interactions in Peyer s patches, J Neuroimmunol, 185. ; Obremski (2014), Changes in Th and Th cytokine concentrations in ileal Peyer s patches in gilts exposed to zearalenone, Pol J Vet Sci, 17, 53. ; Obremski (2003), Influence of zearalenone on reproductive system cell proliferation in gilts, Pol J Vet Sci, 6, 239. ; Obremski (2003), a The level of zearalenone and α - zearalenol in the blood of gilts with clinical symptoms of toxicosis , fed diets with a low zearalenone content, J Anim Feed Sci, 12, 529. ; Bradford (1976), A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein - dye binding, Anal Biochem, 72, 248, ; Zinedine (2007), Review on the toxicity occurrence metabolism detoxification regulations and intake of zearalenone : an oestrogenic mycotoxin, Food Chem Toxicol, 45, 1, ; Mantovani (2007), New vistas on macrophage differentiation and activation, Eur J Immunol, 37, 14, ; Weihe (1991), Molecular anatomy of the neuro - immune connection, Int J Neurosci, 59, 1, ; Strober (2010), Proinflammatory cytokines underlying the inflammation of Crohn s disease, Curr Opin Gastroenterol, 26, 310, ; Arciszewski (2008), Vasoactive intestinal peptide rescues cultured rat myenteric neurons from lipopolysaccharide induced cell death, Regul Pept, 146, 218, ; Gonkowski (2013), Immunohistochemical distribution of cocaine - and amphetamine - regulated transcript peptide like immunoreactive ( CART nerve fibers and various degree of co - localization with other neuronal factors in the circular muscle layer of human descending colon, Histol Histopathol, 28, 851. ; Sirianni (1992), Modulation of human natural killer activity by vasoactive intestinal peptide VIP family VIP glucagon and GHRF specifically inhibit NK activity, Regul Pept, 38, 79, ; Gonkowski (2009), The influence of drug - resistant ulcerative colitis on the number of cocaine - and amphetamine - regulated transcript peptide - like immunoreactive ( CART mucosal nerve fibres of the descending colon in children, Przegląd Gastroenterologiczny, 4, 147. ; Vazquez (2000), Cellular routes of invasion by enteropathogens, Curr Opin Microbiol, 3, 54, ; Bouaziz (2009), Sharaf el dein Fusarial toxin - induced toxicity in cultured cells and in isolated mitochondria involves PTPC - dependent activation of the mitochondrial pathway of apoptosis, Toxicol Sci, 110, 363,