Details
Title
High flow, low shear impellers versus high shear impellers; dispersion of oil drops in water and other examplesJournal title
Chemical and Process EngineeringYearbook
2021Volume
vol. 42Issue
No 2Affiliation
Pacek, Andrzej W. : School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK ; Nienow, Alvin W. : School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UKAuthors
Keywords
high shear/high flow descriptors ; drop sizes ; mixing time ; bioprocessingDivisions of PAS
Nauki TechniczneCoverage
77-90Publisher
Polish Academy of Sciences Committee of Chemical and Process EngineeringBibliography
Arai K., Konno M., Matumagata Y., Saito S., 1977. The effect of dispersed phase viscosity on the maximum stable drop size in turbulent flow. J. Chem. Eng. Jpn., 10, 325–330. DOI: 10.1252/jcej.10.325.Baldyga J., Bourne J.R., Pacek A.W., Amanullah A., Nienow A.W., 2001. Effects of agitation and scale-up on drop size in turbulent dispersions: Allowance for intermittency. Chem. Eng. Sci., 56, 3377–3385. DOI: 10.1016/s0009-2509(01)00027-6.
Chapman C.M., Nienow A.W., Cooke M., Middleton J.C., 1983. Particle-gas-liquid mixing in stirred vessels: Part 2 – gas-liquid mixing. Chem. Eng. Res. Des., 61, 82–95.
Costariol E.,Rotondi M.C., Amini A., Hewitt C.J., NienowA.W., Heathman T.R.J., Rafiq Q.A., 2020. Demonstrating the manufacture of human CAR-T cells in an automated stirred-tank bioreactor. Biotechnol. J., 15, 2000177. DOI: 10.1002/biot.202000177.
Davies J.T., 1985. Droplet sizes of emulsions related to turbulent energy dissipation rates. Chem.Eng. Sci., 40, 839–842. DOI: 10.1016/0009-2509(85)85036-3.
Dyster K.N., Koutsakos E., Jaworski Z., Nienow A.W., 1993. An LDA study of the radial discharge velocities generated by a Rushton turbine: Newtonian fluids, Re ≥ 5. Chem. Eng. Res. Des., 71, 11–23.
Fondy P.L., Bates R.L., 1963.Agitation of liquid systems requiring a high shear characteristic. AIChE J., 9, 338–342. DOI: 10.1002/aic.690090312.
Ghotli R.A., Raman A.A.A., Ibrahim S., Baroutian S., 2013. Liquid – liquid mixing in stirred vessels: A review. Chem. Eng. Comm., 200, 595–627. DOI: 10.1080/00986445.2012.717313.
Hanga M.P., Ali J., Moutsatsou P., de la Raga F.A., Hewitt C.J., NienowA.W,Wall I., 2020.
Bioprocess development for scalable production of cultivated meat. Biotech. Bioeng., 117, 3029–3039. DOI: 10.1002/bit.27469.
Hass V.C., Nienow A.W., 1989. A new axial pumping agitator for the dispersion of gas in liquids. Chem. Ing. Technik, 61, 152–154. DOI: 10.1002/cite.330610213.
Ibrahim S., Nienow A.W., 2004. Suspension of microcarriers for cell culture with axial flow impellers. Chem. Eng. Res. Des., 82, 1082–1088. DOI: 10.1205/cerd.82.9.1082.44161.
Indco, 2021. The difference between high shear and low shear mixing. Available at: https://www.indco.com/blog/indco/2020/03/05/the-difference-between-high-shear-and-low-shear-mixing.
Jaworski Z., Nienow A.W., Dyster K.N., 1996. An LDA study of the turbulent flow field in a baffled vessel agitated by an axial, down-pumping hydrofoil impeller. Can. J. Chem. Eng., 74, 3–15. DOI: 10.1002/cjce.5450740103.
Justen P., Paul G.C., Nienow A.W., Thomas C.R., 1996. Dependence of mycelial morphology on impeller type and agitation intensity. Biotech. Bioeng., 52, 672–684. DOI: 10.1002/(SICI)1097-0290(19961220)52:6672::AIDBIT5> 3.0.CO;2-L.
Langheinrich C., Nienow A.W., Eddleston T., Stevenson N.C., Emery A.N., Clayton T.M, Slater N.K.H., 1998.
Liquid homogenisation studies in animal cell bioreactors of up to 8m3 in volume. Food Bioprod. Process., 76, 107–116. DOI: 10.1205/096030898531873.
Leng D.E., Calabrese R.V., 2004. Immiscible liquid-liquid systems. In: Paul E.L., Atiemo-Obeng V.A., Kresta S.M. (Eds), Handbook of industrial mixing: Science and Practice, John Wiley, New York. 639–753. DOI: 10.1002/0471451452.ch12.
Leng D.E., Calabrese R.V., 2016. Immiscible liquid-liquid systems. In: Kresta S.M., Etchells III A.W., Dickey D.S., Atiemo-Obeng V.A. (Eds), Advances in industrial mixing: A companion to the handbook of industrial mixing. John Wiley, New York. 12, 457–464.
McManameyW.J., 1979. Sauter mean and maximum drop diameters of liquid-liquid dispersions in turbulent agitated vessel at low dispersed phase hold-up. Chem. Eng. Sci., 34, 432–434. DOI: 10.1016/0009-2509(79)85081-2.
Musgrove M., Ruszkowski S., 2000. Influence of impeller type,and agitation conditions on the drop size of immiscible liquid dispersions. Proceedings of the 10th European Conference on Mixing. Delft, the Netherlands, 2–5 July 2000, 165–172. DOI: 10.1016/b978-044450476-0/50022-4.
Nienow A.W., Coopman K., Heathman T.R.J., Rafiq Q.A., Hewitt C.J., 2016. Chapter 3 – Bioreactor engineering fundamentals for stem cell manufacturing. In: Cabral J.M.S. et al (Eds.) Stem Cell Manufacturing. Elsevier Science, Cambridge, USA. 43–75. DOI: 10.1016/B978-0-444-63265-4.00003-0.
Nienow A.W., Scott W.H., Hewitt C.J., Thomas C.R., Lewis G., Amanullah A., Kiss R., Meier S.J., 2013. Scaledown studies for assessing the impact of different stress parameters on growth and product quality during animal cell culture. Chem. Eng. Res. Des., 91, 2265–2274. DOI: 10.1016/j.cherd.2013.04.002.
Nienow A.W., 2021. The impact of fluid dynamic stress in stirred bioreactors-the scale of the biological entity: A personal view. Chem. Ing. Tech., 93, 17–30. DOI: 10.1002/cite.202000176.
Nienow A.W., 1997. On impeller circulation and mixing effectiveness in the turbulent flow regime. Chem. Eng. Sci., 52, 2557–2565. DOI: 10.1016/S0009-2509(97)00072-9.
Nienow A.W., 2014. Stirring and stirred tank reactors. Chem. Ing Tech., 86, 2063–2074. DOI: 10.1002/cite.201400087.
Nienow A.W., Bujalski W., 2002. Recent studies on agitated three phase (gas-liquid-solid) systems in the turbulent regime. Chem. Eng. Res. Des., 80, 832–838. DOI: 10.1205/026387602321143363.
NOV Chemineer, 2021. Available at: https://www.chemineer.com/literature.html.
Oh S.K.W., Nienow A.W., Emery A.N., Al-Rubeai M., 1992. Further studies of the culture of mouse hybridomas in an agitated bioreactor with and without continuous sparging. J. Biotechnol., 22, 245–270. DOI: 10.1016/0168-1656(92)90144-X.
Oldshue J.Y., 1983. Fluid mixing technology and practice, McGraw Hill, New York.
Pacek A.W, Nienow A.W., 1995. A problem for the description of turbulent dispersed liquid-liquid systems. Int. J. Multiphase Flow, 21, 323–325. DOI: 10.1016/0301-9322(94)00068-u.
Pacek A.W, Nienow A.W., Moore I.P.T., 1994b. On the structure of turbulent liquid-liquid dispersed flows in an agitated vessel. Chem. Eng. Sci., 49, 3485–3498. DOI: 10.1016/s0009-2509(94)85027-5.
Pacek A.W., Chamsart S., NienowA.W., Bakker A., 1999. The influence of impeller type on mean drop size and drop size distribution in an agitated vessel. Chem. Eng. Sci., 54, 4211–4222. DOI: 10.1016/s0009-2509(99)00156-6.
Pacek A.W., Moore I.P.T., Calabrese R.V., Nienow A.W., 1993. Evolution of drop size distributions and average drop diameters in liquid-liquid dispersions before and after phase inversion. Chem. Eng. Res. Des., 71, 340–341.
Pacek A.W., Moore I.P.T., Nienow A.W., Calabrese R.V., 1994a. A video technique for the measurement of the dynamics of liquid-liquid dispersion during phase inversion. AIChE J., 40, 1940–1949. DOI: 10.1002/aic.690401203.
Padron D.A., Okonkwo D.A., 2018. Effect of impeller type on drop size of turbulent, non-coalescing liquid-lquid dispersions. 16th European Conference on Mixing, Toulouse, France, 9–12 September 2018.
Paterson G.K., Pauls E.L., Kresta S.M., Etchells A.W., 2015. Mixing and chemical reaction. In: Kresta S.M., Etchells III A.W., Dickey D.S, Atiemo-Obeng V.A. (Eds.), Advances in industrial mixing: A companion to the handbook of industrial mixing. John Wiley, New York. 465–478.
Rotondi M., Grace N., Betts J., Bargh N., Costariol E., Zoro B., Hewitt C.J., Nienow A.W., Rafiq Q.A., 2021. Design and development of a new ambr250r bioreactor vessel for improved cell and gene therapy applications. Biotechnol. Lett., 43, 1103–1116. DOI: 10.1007/s10529-021-03076-3.
Sandadi S., Pedersen H., Bowers J.S., Rendeiro D., 2011. A comprehensive comparison of mixing, mass transfer, Chinese hamster ovary cell growth, and antibody production using Rushton turbine and marine impellers. Bioprocess. Biosyst. Eng., 34, 819. DOI: 10.1007/s00449-011-0532-0.
Sepro Mixing and Pumping, 2021. Mixing basics: Shear and flow. Available at: https://mixing.seprosystems.com/mixing-basics-shear-and-flow/.
Simmons M.J.H., Zhu H, BujalskiW., Hewitt C.J., Nienow A.W., 2007. Mixing in bioreactors using agitators with a high solidity ratio and deep blades. Chem. Eng. Res. Des., 85, 551–559. DOI: 10.1205/cherd06157.
SPX Flow, 2021. Lightnin Mixers. General Overview.Available at: https://www.spxflow.com/assets/pdf/LGT_A400_B-937_US.pdf.
Wille M., Langer G., Werner U., 2001. The influence of macroscopic elongational flow on dispersion processes in agitated tanks. Chem. Eng. Technol., 24, 119–127. DOI: 10.1002/1521-4125(200102)24:2119::aidceat119>3.0.co;2-g.
Date
2021.12.20Type
ArticleIdentifier
DOI: 10.24425/cpe.2021.137342Editorial Board
Editorial Board
Ali Mesbah, UC Berkeley, USA 
0000-0002-1700-0600
Anna Gancarczyk, Institute of Chemical Engineering, Polish Academy of Sciences, Poland 0000-0002-2847-8992
Anna Trusek, Wrocław University of Science and Technology, Poland 0000-0002-3886-7166
Bettina Muster-Slawitsch, AAE Intec, Austria 0000-0002-5944-0831
Daria Camilla Boffito, Polytechnique Montreal, Canada 0000-0002-5252-5752
Donata Konopacka-Łyskawa, Gdańsk University of Technology, Poland 0000-0002-2924-7360
Dorota Antos, Rzeszów University of Technology, Poland 0000-0001-8246-5052
Evgeny Rebrov, University of Warwick, UK 0000-0001-6056-9520
Georgios Stefanidis, National Technical University of Athens, Greece 0000-0002-4347-1350
Ireneusz Grubecki, Bydgoszcz Univeristy of Science and Technology, Poland 0000-0001-5378-3115
Johan Tinge, Fibrant B.V., The Netherlands 0000-0003-1776-9580
Katarzyna Bizon, Cracow University of Technology, Poland 0000-0001-7600-4452
Katarzyna Szymańska, Silesian University of Technology, Poland 0000-0002-1653-9540
Marcin Bizukojć, Łódź University of Technology, Poland 0000-0003-1641-9917
Marek Ochowiak, Poznań University of Technology, Poland 0000-0003-1543-9967
Mirko Skiborowski, Hamburg University of Technology, Germany 0000-0001-9694-963X
Nikola Nikacevic, University of Belgrade, Serbia 0000-0003-1135-5336
Rafał Rakoczy, West Pomeranian University of Technology, Poland 0000-0002-5770-926X
Richard Lakerveld, Hong Kong University of Science and Technology, Hong Kong 0000-0001-7444-2678
Tom van Gerven, KU Leuven, Belgium 0000-0003-2051-5696
Tomasz Sosnowski, Warsaw University of Technology, Poland 0000-0002-6775-3766