Tytuł artykułu

Parasiticidal effects of Eclipta alba and Arctium lappa extracts against Ichthyophthirius multifiliis

Tytuł czasopisma

Polish Journal of Veterinary Sciences




vol. 24


No 4


Leśniak, P. : Department of Biology and Fish Diseases, Faculty of Veterinary Medicine, University of Life Sciences, Akademicka 12, 20-033, Lublin, Poland ; Puk, K. : Department of Biology and Fish Diseases, Faculty of Veterinary Medicine, University of Life Sciences, Akademicka 12, 20-033, Lublin, Poland ; Guz, L. : Department of Biology and Fish Diseases, Faculty of Veterinary Medicine, University of Life Sciences, Akademicka 12, 20-033, Lublin, Poland


Słowa kluczowe

fish ; Ichthyophthirius multifiliis ; parasite ; Eclipta alba ; Arctium lappa

Wydział PAN

Nauki Biologiczne i Rolnicze




Polish Academy of Sciences Committee of Veterinary Sciences ; University of Warmia and Mazury in Olsztyn


Ahangarpour A, Heidari H, Oroojan AA, Mirzavandi F, Nasr Esfehani K, Dehghan Mohammadi Z (2017) Antidiabetic, hypolipidemic and hepatoprotective effects of Arctium lappa root›s hydro-alcoholic extract on nicotinamide-streptozotocin induced type 2 model of diabetes in male mice. Avicenna J Phytomed 7: 169-179.

Bhinge SD, Hogade MG, Chavan C, Kumbhar M, Chature V (2010) In vitro anthelmintic activity of herb extract of Eclipta prostrate L. against Pheretima posthuma. Asian J Pharm Clin Res 3: 229-230.

Boregowda RS, Murali N, Udayashankar AC, Niranjana SR, Lund OS, Prakash HS (2019) Antifungal activity of Eclipta alba metabolites against sorghum pathogens. Plants 8: 72.

Buchmann K, Jensen PB, Kruse KD (2003) Effects of sodium percarbonate and garlic extract on Ichthyophthirius multifiliis theronts and tomocysts: in vitro experiments. N Am J Aquac 65: 21-24.

Chan YS, Cheng LN, Wu JH, Chan E, Kwan YW, Lee SM, Leung GP, Yu PH, Chan SW (2011) A review of the pharmacological effects of Arctium lappa (burdock). Inflammopharmacology 19: 245-254.

Chaudhary H, Dhuna V, Singh J, Kamboj SS, Seshadri S (2011) Evaluation of hydro-alcoholic extract of Eclipta alba for its anticancer poten-tial: an in vitro study. J Ethnopharmacol 136: 363-367.

De Almeida AB, Luiz-Ferreira A, Cola M, Di Pietro Magri L, Batista LM, de Paiva JA, Trigo JR, Souza-Brito AR (2012) Anti-ulcerogenic mechanisms of the sesquiterpene lactone onopordopicrin-enriched fraction from Arctium lappa L. (Asteraceae): role of somatostatin, gastrin, and endogenous sulfhydryls and nitric oxide. J Med Food 15: 378-383.

De Souza AR, Guedes AR, Rodriguez JM, Bombardelli MC, Corazza ML (2018) Extraction of Arctium lappa leaves using supercritical CO2+ethanol: Kinetics, chemical composition, and bioactivity assessments. J Supercrit Fluids 140: 137-146.

Dickerson H, Dawe D (1995) Ichthyophthirius multifiliis and Cryptocaryon irritans (Phylum Ciliophora). In: Woo PTK (ed) Fish diseases and disorders, vol 1. Protozoan and metazoan infections. CAB International, Wallingford.

Dos Santos AC, Baggio CH, Freitas CS, Lepieszynski J, Mayer B, Twardowschy A, Missau FC, Santos ÉP, Pizzolatti MG, Marques MC (2008). Gastroprotective activity of the chloroform extract of the roots from Arctium lappa L. J Pharm Pharmacol 60: 795-801.

Ekanem AP, Obiekezie A, Kloas W, Knopf K (2004) Effects of crude extracts of Mucuna pruriens (Fabaceae) and Carica papaya (Carica-ceae) against the protozoan fish parasite Ichthyophthirius multifiliis. Parasitol Res 92: 361-366.

Ferracane R, Graziani G, Gallo M, Fogliano V, Ritieni A (2010) Metabolic profile of the bioactive compounds of burdock (Arctium lappa) seeds, roots and leaves. J Pharm Biomed Anal 51: 399-404.

Forwood JM, Harris JO, Landos M, Deveney MR (2014) Evaluation of treatment methods using sodium percarbonate and formalin on Aus-tralian rainbow trout farms. Aquac Eng 63: 9-15.

Fu YW, Zhang QZ, Xu DH, Liang JH, Wang B (2014a) Antiparasitic Effect of cynatratoside-C from Cynanchum atratum against Ichthy-ophthirius multifiliis on Grass Carp. J Agric Food Chem 62: 7183-7189.

Fu YW, Zhang QZ, Xu DH, Xia H, Cai XX, Wang B, Liang J (2014) Parasiticidal effects of Morus alba root bark extracts against Ichthy-ophthirius multifiliis infecting grass carp. Dis Aquat Organ 108: 129-136.

Gao Q, Yang M, Zuo Z (2018) Overview of the anti-inflammatory effects, pharmacokinetic properties and clinical efficacies of arctigenin and arctiin from Arctium lappa L. Acta Pharmacol Sin 39: 787-801.

Govindarajan M, Karuppannan P (2011). Mosquito larvicidal and ovicidal properties of Eclipta alba (L.) Hassk (Asteraceae) against chikungunya vector, Aedes aegypti (Linn.) (Diptera: Culicidae). Asian Pac J Trop Med 4: 24-28.

Han Y, Xia C, Cheng X, Xiang R, Liu H, Yan Q, Xu D (1998) Preliminary studies on chemical constituents and pharmacological action of Eclipta prostrata L, Zhongguo Zhong Yao Za Zhi 23: 680-682.

Holetz FB, Pessini GL, Sanches NR, Cortez DA, Nakamura CV, Filho BP (2002) Screening of some plants used in the Brazilian folk medi-cine for the treatment of infectious diseases. Mem Inst Oswaldo Cruz 97: 1027-1031.

Huang TC, Tsai SS, Liu LF, Liu YL, Liu HJ, Chuang KP (2010) Effect of Arctium lappa L. in the dextran sulfate sodium colitis mouse mod-el. World J Gastroenterol 16: 4193-4199.

Husain M, Anis M (2006) Rapid in vitro propagation of Eclipta alba (L.) Hassk. Through high frequency axillary shoot proliferation. Acta Physiol Plant 28: 325-330.

Jørgensen LG (2017) The fish parasite Ichthyophthirius multifiliis - Host immunology, vaccines and novel treatments. Fish Shellfish Immunol 67: 586-595.

Knipping K, van Esch EC, Wijering SC, van der Heide S, Dubois AE, Garssen J (2008) In vitro and in vivo antiallergic effects of Arctium lappa L. Exp Biol Med (Maywood) 233: 1469-1477.

Kumar G, Karthik L, Rao KV (2011) Hemolytic activity of Indian medicinal plants towards human erythrocytes: An in vitro study. Elixir Appl Botany 40: 5534-5537.

Kumari CS, Govindasamy S, Sukumar E (2006) Lipid lowering activity of Eclipta prostata in experimental hyperlipidemia. J Ethnopharmacol 105: 332-335.

Lin SC, Yao CJ, Lin CC, Lin YH (1998) Hepatoprotective Activity of Taiwan Folk Medicine: Eclipta prostrata Linn. against various hepato-toxins induced acute hepatotoxicity. Phytother Res 10: 483-490.

Ling F, Wang JG, Lu C, Wang GX, Lui YH, Gong XN (2012) Effects of aqueous extract of Capsicum frutescens (Solanaceae) against the fish ectoparasite Ichthyophthirius multifiliis. Parasitol Res 111: 841-848.

Ling KH, Sin YM, Lam TJ (1993) Effect of copper sulphate on ichthyophthiriasis (white spot disease) in goldfish (Carassius auratus). Aq-uaculture (Netherlands) 118: 23-35.

Manvar D, Mishra M, Kumar S, Pandey VN (2012) Identification and evaluation of anti hepatitis C virus phytochemicals from Eclipta alba. J Ethnopharmacol 144: 545-554.

Matthews RA (2005) Ichthyophthirius multifiliis Fouquet and ichthyophthiriosis in freshwater teleosts. Adv Parasitol 59: 159-241.

Nascimento BA, Gardinassi LG, Silveira IM, Gallucci MG, Tomé MA, Oliveira JF, Moreira MR, Meirelles AF, Faccioli LH, Tefé-Silva C, Zoccal KF (2019) Arctium lappa extract suppresses inflammation and inhibits melanoma progression. Medicines (Basel) 6: 81.

Newman DJ, Cragg GM, Snader KM (2003) Natural products as sources of new drugs over the period 1981-2002. J Nat Prod 66: 1022-1037.

Puk K, Guz L (2021) Parasiticidal effects of Tanacetum vulgare extract against Ichthyophthirius multifiliis. Pol J Vet Sci 24: 159-161.

Sawant M, Isaac JC, Narayanan S (2004) Analgesic studies on total alkacoloids and alcohol extrats of Eclipta alba (Linn.) Hassk. Phytother Res 18: 111-113.

Saxena AK, Singh B, Anand KK (1993) Hepatoprotective effects of Eclipta alba on subcellular levels in rats. J Ethnopharmacol 40: 155-161.

Singh B, Saxena AK, Chandan BK, Agarwal SG, Anand KK (2001) In vivo hepatoprotective activity of active fraction from ethanolic extract of Eclipta alba leaves. Indian J Physiol Pharmacol 45: 435-441.

Srivastava S, Sinha R, Roy D (2004) Toxicological effects of malachite green. Aquat Toxicol 66: 319-329.

Straus DL, Griffin BR (2002) Efficacy of potassium permanganate in treating ichthyophthiriasis in channel catfish. J Aquat Anim Health 14: 145-148.

Tieman DM, Goodwin AE (2001) Treatments for Ich infestations in channel catfish evaluated under static and flow-through water conditions. N Am J Aquac 63: 293-299.

Valladao GM, Gallani SU, Pilarski F (2015) Phytotherapy as an alternative for treating fish disease. J Vet Pharmacol Ther 38: 417-428.

Wong SM, Antus S, Gottsegen A, Fessler B, Rao GS, Sonnenbichler J, Wagner H (1988) Wedelolactone and coumestan derivatives as new antihepatotoxic and antiphlogistic principles. Arzneimittelforschung 38: 661-665.

Yi YL, Lu C, Hu XG, Ling F, Wang GX (2012) Antiprotozoal activity of medicinal plants against Ichthyophthirius multifiliis in goldfish (Carassius auratus). Parasitol Res 111: 1771-1778.

Zhang Q, Xu DH, Klesius PH (2013) Evaluation of an antiparasitic compound extracted from Galla chinensis against fish parasite Ichthy-ophthirius multifiliis. Vet Parasitol 198: 45-53.






DOI: 10.24425/pjvs.2021.139979 ; ISSN 1505-1773