Ascophyllum nodosum as a nutrient supporting oral health in dogs and cats: a review

Journal title

Polish Journal of Veterinary Sciences




vol. 26


No 3


Gawor, J. : Klinika Arka, Chłopska 2a, 30-806 Krakow, Poland ; Jank, M. : Institute of Veterinary Medicine, Department of Pre-Clinical Sciences, Warsaw University of Life Sciences, Ciszewskiego 8, 02-786 Warsaw, Poland



Ascophyllum nodosum ; oral health ; oral hygiene ; nutrient ; dogs ; cats

Divisions of PAS

Nauki Biologiczne i Rolnicze




Polish Academy of Sciences Committee of Veterinary Sciences ; University of Warmia and Mazury in Olsztyn


  1. Anthony JM, Weber LP, Alkemade S (2011) Blood glucose and liver function in dogs administered a xylitol drinking water additive at zero, one and five times dosage rates. Vet Sci Develop 1: e2.
  2. Bjone S, Brown W, Harris A, Genity PM (2007) Influence of chewing on dental health in dogs. In: Proc. 16th European Congress of Veterinary Dentistry, pp 45-46.
  3. Borah BM, Halter TJ, Xie B, Henneman ZJ, Siudzinski TR, Harris S, Elliott M, Nancollas GH (2014) Kinetics of canine dental calculus crystallization: an in vitro study on the influence of inorganic components of canine saliva. J Colloid Interface Sci. 425: 20-26.
  4. Boyce EN, Ching RJ, Logan EI, Hunt JH, Maseman DC, Gaeddert KL, King CT, Reid EE, Hefferren JJ (1995) Occurrence of gram-negative black-pigmented anaerobes in subgingival plaque during the development of canine periodontal disease. Clin Infect Dis 20 (Suppl 2): S317-S319.
  5. Bringel M, Jorge PK, Francisco PA, Lowe C, Sabino-Silva R, Colombini-Ishikiriama BL, Machado MAAM, Siqueira WL (2020) Salivary proteomic profile of dogs with and without dental calculus. BMC Vet Res. 16(1): 298.
  6. Brown WY, McGenity P (2005) Effective periodontal disease control using dental hygiene chews. J Vet Dent 22: 16-19.
  7. Capik I (2007) Periodontal health vs. different preventative means in toy breeds – clinical study. In: Proc.16th European Congress of Veterinary Dentistry, pp 31-34.
  8. Chapek CW, Reed OK, Ratcliff PA (1995) Reduction of bleeding on probing with oral-care products. Compend Contin Educ Dent 16: 188-192.
  9. Clarke DE (2006) Drinking water additive decreases plaque and calculus accumulation in cats. J Vet Dent 23: 79-82.
  10. Corba NH, Jansen J, Pilot T (1986) Artificial periodontal defects and frequency of tooth brushing in beagle dogs (II). Clinical findings after a period of healing. J Clin Periodontol 13: 186-189.
  11. Debowes LJ (2010) Problems with the gingiva. In: Niemiec BA (ed) Small animal dental, oral and maxillofacial disease, A color handbook; Manson, London, UK, pp 159-181.
  12. Della Riccia DN, Bizzini F, Perilli MG, Plimeni A, Trinchieri V, Amicosante G, Cifone MG (2007) Anti-inflammatory effects of lactobacillus brevis (CD2) on periodontal disease. Oral Dis 13: 376-385.
  13. Dunayer EK (2004) Hypoglycemia following canine ingestion of xylitol-containing gum. Vet Hum Toxicol 46: 87-88.
  14. Dunayer EK (2006) New findings on the effects of xylitol ingestion in dogs. Vet Med 101: 791-797.
  15. DuPont GA (1998) Prevention of periodontal disease. Vet Clin North Am Small Anim Pract. 28(5): 1129-1145.
  16. Fiorellini JP, Ishikawa SO, Kim DM (2006) Clinical Features of Gingivitis. In: Carranza’s Clinical Periodontology. WB Saunders, St. Louis, USA, pp 362-372.
  17. Gawor J, Jank M (2019) The curative usage of Ascophyllum nodosum powder in cats with periodontal disease (data not published, available in Authors)
  18. Gawor J, Jank M, Jodkowska K, Klim E, Svensson UK (2018) Effects of Edible Treats Containing Ascophyllum nodosum on the Oral Health of Dogs: A Double-Blind, Randomized, Placebo-Controlled Single-Center Study. Front Vet Sci 27: 168.
  19. Gawor J, Reiter AM, Jodkowska K, Kurski G, Wojtacki MP, Kurek A (2006) Influence of diet on oral health in cats and dogs. J Nutr 136: 2021S-2023S.
  20. Gawor JP, Wilczak J, Svensson UK, Jank M (2021) Influence of dietary supplementation with a powder containing Ascophyllum Nodosum algae on dog saliva metabolome. Front Vet Sci 8: 81951.
  21. Goñi O, Quille P, O’Connell S (2018) Ascophyllum nodosum extract biostimulants and their role in enhancing tolerance to drought stress in tomato plants. Plant Physiol Biochem 126: 63-73.
  22. Hale FA (2003) Home care for the veterinary dental patient. J Vet Dent 20: 52-54.
  23. Hamp SE, Emilson CG (1973) Some effects of chlorhexidine on the plaque flora of the beagle dog. J Periodontol Res 12: 28-35.
  24. Harvey CE (2005) Management of periodontal disease: understanding the options. Vet Clin North Am Small Anim Pract. 5(4): 819-836.
  25. Harvey CE, Shofer FS, Laster L (1996) Correlation of diet, other chewing activities, and periodontal disease in North American Client-owned dogs. J Vet Dent 13: 101-105.
  26. Hasturk H, Goguet-Surmenian E, Blackwood A, Andry C, Kantarci A (2009) 1-Tetradecanol complex: Therapeutic actions in experimental periodontitis. J Periodontol 80: 1103-1113.
  27. Hasturk H, Jones VL, Andry C, Kantarci A (2007) 1-Tetradecanol complex reduces progression of Porphyromonas gingivalis-induced experimental periodontitis in rabbits. J Periodontol 78: 924-932.
  28. Hennet P, Servet E, Salesse H, Soulard Y (2006) Evaluation of the Logan and Boyce Plaque Index for the Study of Dental Plaque Accumulation in Dogs. Res Vet Sci 80: 175-180.
  29. Hennet P, Servet E, Soulard Y, Biourge V (2007) Effect of pellet food size and polyphosphates in preventing calculus accumulation in dogs. J Vet Dent 24: 236-239.
  30. Hennet P, Servet E, Venet C (2006) Effectiveness of an oral hygiene chew to reduce dental deposits in small breed dogs. J Vet Dent 23: 6-12.
  31. Jank M (2021) Nutrition, oral health and feeding dental patients. In: Gawor J, Niemiec BA (eds) Veterinary Dental Patient. A Multidisciplinary approach. John Wiley and Sons, Hoboken, USA, pp 75-86.
  32. Jensen L, Logan E, Finney O, Lowry S, Smith M, Hefferren J, Simone A, Richardson D (1995) Reduction in accumulation of plaque, stain, and calculus in dogs by dietary means. J Vet Dent 12: 161-163.
  33. Kwon T, Lamster IB, Levin L (2021) Current concepts in the management of periodontitis. Int Dent J. 71(6): 462-476.
  34. Lage A, Lausen N, Tracy R, Allred E (1990) Effect of chewing rawhide and cereal biscuit on removal of dental calculus in dogs. J. Am Vet Med Assoc 197: 213-219.
  35. Lappin DF, Kjeldsen M, Sander L, Kinane DF (2000) Inducible nitric oxide synthase expression in periodontitis. J Periodontal Res 35: 369-373.
  36. Larsen J (2010) Oral products and dental disease. Comp Contin Educ Vet 32(9): E1-3.
  37. Liu H, Segreto VA, Baker RA, Vastola KA, Ramsey LL, Gerlach RW (2002) Anticalculus efficacy and safety of a novel whitening dentifrice containing sodium hexametaphosphate: a controlled six-month clinical trial. J Clin Dent 13: 25-28.
  38. Loe H (1967) The gingival index, the plaque index and the retention index systems. J Periodontol 38(6)Suppl: 610-616.
  39. Logan EI, Berg ML, Coffman L. et al. (1999) Dietary control of feline gingivitis: results of a six-month study. In: Proc. 13th Veterinary Dental Forum, pp 54.
  40. Logan EI, Boyce EN (1994) Oral health assessment in dogs: parameters and methods. J Vet Dent 11: 58-63.
  41. Logan EI, Finney O, Hefferren JJ (2002) Effects of a dental food on plaque accumulation and gingival health in dogs. J Vet Dent 19: 15-18.
  42. Logan EI, Proctor V, Berg ML, Coffman L, Hefferren JJ (2001) Dietary effect on tooth surface debris and gingival health in cats. In: Proc. 15th Annual American Veterinary Dental Forum, San Antonio, USA, p 377.
  43. Logan EI, Wiggs RB, Zetner K, Hefferren JJ (2000) Dental disease. In: Small animal clinical nutrition. 4th ed., Hand MS, Thacher CD, Remillard RL, Roudebush P (eds) Mark Morris Institute, Topeka KS, USA, pp 475-492.
  44. Matejka M, Partyka L, Ulm C, Solar P, Sinzinger H (1998) Nitric oxide synthesis is increased in periodontal disease. J Periodontal Res 33: 517-518.
  45. Milella L (2015) The negative effects of volatile sulphur compounds. J Vet Dent 32: 99–102.
  46. Moreira R, Sineiro J, Chenlo F, Arufe S, Díaz-Varela D (2017) Aqueous extracts of Ascophyllum nodosum obtained by ultrasound-assisted extraction: effects of drying temperature of seaweed on the properties of extracts. J Appl Phycol 29: 3191-3200.
  47. Needleman I, Suvan J, Moles DR, Pimlott J (2005) A systematic review of professional mechanical plaque removal for prevention of periodontal diseases. J Clin Periodontol 32 (Supp 6): 229-282.
  48. Niemiec B, Gawor J, Nemec A, Clarke D, McLeod K, Tutt C, Gioso M, Steagall PV, Chandler M, Morgenegg G, Jouppi R. McLeod K (2020) World small animal veterinary association global dental guidelines. J Small Anim Pract. 61(7): 395-403.
  49. Niemiec BA (2003) Professional teeth cleaning. J Vet Dent 20(3): 175-180.
  50. Niemiec BA (2021) Prophylactic Program for Oral Health. In: Gawor J, Niemiec BA (eds) Veterinary Dental Patient. A Multidisciplinary approach. John Wiley and Sons, Hoboken, USA, pp 59-62.
  51. Patent (2000) Oral preparation containing seaweed for reduction of plaque and calculus. International Patent Classification PCT/SE01/02083. 27.10.2000
  52. Paquette DW, Williams RC (2000) Modulation of host inflammatory mediators as a treatment strategy for periodontal diseases. Periodontology 24: 239-252.
  53. Payne WA, Page RC, Ogilvie AL, Hall WB (1975) Histopathologic features of the initial and early stages of experimental gingivitis in man. J Periodontal Res 10: 51.
  54. Perry DA (2006) Plaque control for the periodontal patient. In: Carranza’s Clinical Periodontology. WB Saunders, St. Louis, USA, pp 728-748.
  55. Pihlstrom BL, Michalowicz BS, Johnson NW (2005) Periodontal diseases. Lancet 366(9499): 1809-1820.
  56. Rawlings JM, Gorrel C, Markwell PJ (1998) Effect on Canine oral health of adding chlorhexidine to a dental hygiene chew. J Vet Dent 15: 129-134.
  57. Ray JD Jr, Eubanks DL (2009) Dental homecare: teaching your clients to care for their pet’s teeth. J Vet Dent 26(1): 57-60.
  58. Roudebush P, Logan E, Hale FA (2005) Evidence-based veterinary dentistry: a systematic review of homecare for prevention of periodontal disease in dogs and cats. J Vet Dent 22: 6-15.
  59. Shukla PS, Mantin EG, Adil M, Bajpai S, Critchley AT, Prithiviraj B (2019) Ascophyllum nodosum-Based Biostimulants: Sustainable Applications in Agriculture for the Stimulation of Plant Growth, Stress Tolerance, and Disease Management. Front Plant Sci 10: 655.
  60. Stookey GK, Warrick JM, Miller LL, Katz BP (1996) Hexametphosphate-coated snack biscuits significantly reduce calculus formation in dogs. J Vet Dent 13: 270-279.
  61. Tibbitts L, Kashiwa H (1970) A histochemical study of early plaque mineralization. J Dent Res 119: 202.
  62. van Dijken JW, Koistinen S, Ramberg P (2015) A randomized controlled clinical study of the effect of daily intake of Ascophyllum nodosum alga on calculus, plaque, and gingivitis. Clin Oral Investig 19: 1507-1518.
  63. Vrieling HE, Theyse LF, van Winkelhoff AJ, Dijkshoorn NA, Logan EI, Picavet P (2005) Effectiveness of feeding large kibbles with mechanical cleaning properties in cats with gingivitis. Tijdschr Diergeneeskd 130: 136-40.
  64. Warric JM, Stookey GK, Inskeep GA, Inskeep TK (2001) Reducing calculus accumulation in dogs using an innovative rawhide treat system coated with Hexametaphosphate. In: Proc. 15th Annual American Veterinary Dental Forum, San Antonio, USA, 379-382.
  65. White DJ, Cox ER, Suszcynskymeister E, Baig AA (2002) In vitro studies of the anticalculus efficacy of a sodium hexametaphosphate whitening dentifrice. J Clin Dent 13: 33-37.
  66. Wiggs RB, Lobprise HB (1997) Periodontology in veterinary dentistry, principals and practice. Lippincott – Raven: Philadelphia, USA, pp 186-231.
  67. VOHC Report (2018) Submission to VOHC for claims on Helps Control Plaque and Helps Control Tartar in dogs receiving product ProDen PlaqueOff Powder. Submitted 2018.10.22.
  68. VOHC Report (2020a) Submission to VOHC regarding application for use of the VOHC seal for the product Pro Den Plaque Off Powder from Swedencare AB. Submitted 2020.09.10.
  69. VOHC Report (2020b) Submission to VOHC regarding application for use of the VOHC seal for the product Canagan Dental For Dogs from Symply Pet Foods Ltd. Submitted 2020.10.01.
  70. Xia Z, He Y, Yu J (2009) Experimental acute toxicity of xylitol in dogs. J Vet Pharmacol Therapeutics 32: 465-469.


Review paper


DOI: 10.24425/pjvs.2023.145053