Abstract
Taking bacterial virulence factors as targets is a new therapy for treating host bacterial infection.
The aim of this study was to investigate the effect of matrine on α-hemolysin production of Staphylococcus
aureus (S. aureus) and reducing the damage to bovine mammary epithelial cells (BMECs) induced by
S. aureus α-hemolysin. Subinhibitory concentrations of matrine decreased the production of α-hemolysin
in none dose-dependent manner and matrine exhibited a protective effect on S. aureus-induced BMECs
injury. The results indicated that the structure of matrine may potentially be used as a basic structure for
development of drugs aimed at curing and preventing dairy bovine mastitis.
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