This study aims to determine optimal forming parameters for Incremental Sheet Forming process Commercially Pure titanium Grade 2 sheets in terms of formability improvement, force reduction, and efficiency of forming. Based on the central composite design, data were collected during 20 runs and then variation analysis was performed. The experiments were performed on a 3 axis CNC milling machine equipped with a Kistler dynamometer plate. Subsequently, regression models have been developed to describe process responses by input factors. As crucial parameters, the relative velocity and step size of the tool that affect the forming force and the height of the fracture have been determined. Finally, the application of optimization algorithm has emerged optimal input factors in terms of selected multi-criteria goal. The results of this study suggest that there is a process window that allows the formation of 45° wall angle drawpieces of commercially pure titanium Grade 2.