Search results

Filters

  • Journals
  • Authors
  • Keywords
  • Date
  • Type

Search results

Number of results: 138
items per page: 25 50 75
Sort by:
Download PDF Download RIS Download Bibtex

Abstract

Perovskite solar cells represent the biggest breakthrough in photovoltaics in decades, bringing a chance for affordable and widely available green energy. They are suitable in areas where silicon cells have fallen short.
Go to article

Authors and Affiliations

Olaf Szewczyk
1

  1. Saule Technologies in Warsaw
Download PDF Download RIS Download Bibtex

Abstract

The photoacoustic cell is the heart of the nondestructive photoacoustic method. This article presents a new simple lumped-components CRLC model of the Helmholtz type photoacoustic cell. This model has been compared with the well known literature models describing the Helmholtz type cells for photoacoustic spectroscopy. Experimental amplitude and phase frequency data obtained for the two photoacoustic cells have been presented and interpreted in a series of models. Results of the fitting of theoretical curves, obtained in these models, to the experimental data have been shown and discussed.

Go to article

Authors and Affiliations

Łukasz Bartłomiej Chrobak
Mirosław Andrzej Maliński
Download PDF Download RIS Download Bibtex

Abstract

The application of renewable energy sources poses the problems connected with output volatility. In order to decrease this effect the energy storage technologies can be applied, particularly fuel cells connected with hydrogen storage. In this paper the application of SOFC system for a household in Poland is proposed. Economic and technical analysis is performed. It was found that the proposed installation is profitable after 25 years of operation when compared with conventional solution - heat pumps and gas-fired boilers.

Go to article

Authors and Affiliations

Maciej Cholewiński
Łukasz Tomków
Download PDF Download RIS Download Bibtex

Abstract

The aim of the present study was to investigate whether the anterior chamber constitutes part of the normal migratory pathway of CD4+ and CD8+ lymphocytes in cattle and swine. The cells obtained from aqueous humor of cows and pigs were stained for CD4 and CD8 receptors, and subsequently analyzed with flow cytometry. The mean percentage of CD4+CD8-, CD4-CD8+ and CD4+CD8+ cells within the total lymphocyte population of the bovine anterior chamber was, respectively, 17.88, 12.64 and 27.26%. In turn, the mean values of these parameters in pigs were 1.77, 38.48 and 17.45, respectively. Among bovine and porcine CD4+CD8+ cells prevalent were those displaying CD4lowCD8low and CD4lowCD8high phenotypes, respectively. The results suggest that the anterior chamber in cattle and swine is an element in the normal migratory pathway of CD4+, CD8+ and CD4+CD8+ cells. Furthermore, the contribution of these subsets in the anterior chamber lymphocyte population can differ considerably between animal species.
Go to article

Authors and Affiliations

H. Ziółkowski
T. Maślanka
P. Socha
N. Ziółkowska
M. Dąbrowski
J. Małaczewska
Download PDF Download RIS Download Bibtex

Abstract

Feeder cells can promote cell proliferation and help overcome the developmental arrest of early embryos by producing growth factors. The objective of this study was to evaluate the effects of feeder cells on the development of all single porcine parthenogenetic embryos in vitro. Firstly, we showed that the cleavage and blastocyst formation rate of all single procine parthenogenetic embryos co-cultured with feeder cells increased in contrast to those cultured without feeder cells (p<0.05). However, no statistically significant differences were observed between the blastocyst formation rate in the embryos co-cultured with 3 different kinds feeder cells namely oviduct epithelial feeder cells, granulose feeder cells and porcine fetal fibroblast feeder cells (p>0.05). Secondly, highly significant differences were observed between the cleavage and blastocyst formation rate (p<0.05) when the embryos were co-cultured with oviduct epithelial feeder cells in different volume drops ranging from 3 to 20 μL and the cleavage rate were the highest when cultured in 5 μL drops. Thirdly, the tempospacial pattern of the development of single embryos co-cultured with oviduct epithelial feeder cells was consistent with that of traditional multi-embryo culture, indicating that the co-culturing does not affect the developmental competence of the porcine parthenogenetic embryos. Finally, highly significant differences were observed between the cleavage and blastocyst formation rate with and without zona pellucida in vitro (p<0.05). In this study, a new adaption of in vitro co-culture of single porcine parthenogenetic embryos using feeder cells has been successfully established and this will facilitate further investigations to discover the mechanistic mode of developmental arrest of porcine embryos.

Go to article

Authors and Affiliations

L. Zhang
Z. Lin
Z. Hua
X. Zheng
H. Xiao
W. Hua
H. Ren
Z. Zhu
A. Molenaar
Y. Bi
Download PDF Download RIS Download Bibtex

Abstract

The paper presents a solidification sequence of graphite eutectic cells of A and D types, as well as globular and cementite eutectics. The morphology of eutectic cells in cast iron, the equations for their growth and the distances between the graphite precipitations in A and D eutectic types were analyzed. It is observed a critical eutectic growth rate at which one type of eutectic transformed into another. A mathematical formula was derived that combined the maximum degree of undercooling, the cooling rate of cast iron, eutectic cell count and the eutectic growth rate. One type of eutectic structure turned smoothly into the other at a particular transition rate, transformation temperature and transformational eutectic cell count. Inoculation of cast iron increased the number of eutectic cells with flake graphite and the graphite nodule count in ductile iron, while reducing the undercooling. An increase in intensity of inoculation caused a smooth transition from a cementite eutectic structure to a mixture of cementite and D type eutectic structure, then to a mixture of D and A types of eutectics up to the presence of only the A type of eutectic structure. Moreover, the mechanism of inoculation of cast iron was studied.
Go to article

Authors and Affiliations

M. Górny
E. Fraś
Download PDF Download RIS Download Bibtex

Abstract

Thin film solar cells based on multinary compound Cu(In,Ga)Se2 show record photovoltaic conversion efficiency approaching 20%. Investigation on defect physics in this compound is crucial for making further progress in the technology. In this work we present the results on photocapacitance (PC) and deep level optical spectroscopy (DLOS) for two types of cells – high efficiency Cu(In,Ga)Se2 cell with about 20% of gallium and pure gallium CuGaSe2 device. We show that PC and DLOS, employed as the techniques complimentary to deep level transient spectroscopy DLTS and admittance spectroscopy, are useful methods in providing information on defect levels in solar cells. In particular they are helpful in diffierentiating between levels belonging to the bulk of absorber and to the interface states. We tentatively assign some of the observed deep levels to InCu or GaCu antisites and Cu interstitials.

Go to article

Authors and Affiliations

M. Igalson
A. Urbaniak
Download PDF Download RIS Download Bibtex

Abstract

Malakoplakia is regarded as a chronic granulomatous infl ammatory disease with a good prognosis. It usually aff ects the urinary system, especially the urinary bladder. Bacterial infections, including E. coli are thought to be the main factor in pathogenesis. It frequently coexists with chronic diseases and immunosuppression state. Histopathological examination of aff ected tissue samples is thought to be the best diagnostic method. Th e basic microscopic feature is mixed infl ammatory infi ltration containing foamy histiocytes known as von Hansemann cells, frequently with basophilic inclusions known as Michaelis-Gutmann bodies. Symptoms and the clinical course of malakoplakia depend on location and the extent of the lesions. Th e lesion is treated successfully with antibiotic therapy and surgical excision.

Go to article

Authors and Affiliations

Katarzyna Cięszczyk
Michał Puderecki
Lech Wronecki
Franciszek Burdan
Justyna Szumiło
Download PDF Download RIS Download Bibtex

Abstract

Prof. Stanisław Karpiński discusses groundbreaking research into how plants communicate, remember stress, and process information.
Go to article

Authors and Affiliations

Stanisław Karpiński
1

  1. Warsaw University of Life Sciences (SGGW)
Download PDF Download RIS Download Bibtex

Abstract

Telocyte (TC) is an interstitial cell type with a small cellular body and extremely long tentacle-like extensions. TCs were discovered a decade ago and have specific morphological characteristics, immunohistochemical and secretome profi les, electrophysiological properties, microRNA expression. Moreover, they are different in gene expression from other cells. TCs play an important role in plenty of processes. Apparently, they are involved in homeostasis, remodelling, regeneration, repair, embryogenesis, angiogenesis and even tumorigenesis. “Telocytes need the world”, was emphasized by Professor Popescu and it will be actual at any time. This review summarizes particular features of TCs in different organs and systems, emphasizing their involvement in physiological and pathophysiological processes.

Go to article

Authors and Affiliations

Veronika Aleksandrovych
Artur Pasternak
Paweł Basta
Marek Sajewicz
Jerzy A. Walocha
Krzysztof Gil
Download PDF Download RIS Download Bibtex

Abstract

In pursuit of increased efficiency and longer operating times of photovoltaic systems, one may encounter numerous difficulties in the form of defects that occur in both individual solar cells and whole modules. The causes of the occurrence range from structural defects to damage during assembly or, finally, wear and tear of the material due to operation. This article provides an overview of modern imaging methods used to detect various types of defects found in photovoltaic cells and panels. The first part reviews typical defects. The second part of the paper reviews imaging methods with examples of the authors’ own test results. The article concludes with recommendations and tables that provide a kind of comprehensive guide to the methods described, depending on the type of defects detected, the range of applicability, etc. The authors also shared their speculations on current trends and the possible path for further development and research in the field of solar cell defect analysis using imaging.
Go to article

Authors and Affiliations

Maurycy Maziuk
1
Laura Jasińska
1
Jarosław Domaradzki
1
Paweł Chodasewicz
1

  1. Wrocław University of Science and Technology, Faculty of Electronic, Photonics and Microsystems, Department ofElectronic and Photonic Metrology, Division of Thin Film Technologies, Wybrzeze Wyspianskiego 27, 50-370 Wrocław,Poland
Download PDF Download RIS Download Bibtex

Abstract

In the recent times, lot of research work carried out in the field of fuel cells explicitly divulges that it has the potential to be an ultimate power source in upcoming years. The fuel cell has more storing capacity, which enables to use in heavy power applications. In these applications, power conditioning is more vital to regulate the output voltage. Hence, we need a dc-dc converter to provide a constant regulated output voltage for such high-power system. Currently, many new converters were designed and implemented as per the requirement. This paper has made comparative study on several topologies of the quadratic high gain dc-dc converter and the applications where these topologies can be used when the fuel cell is given as a source. Also, we have compared various parameters of all the converters considered and generated the results with steady-state and dynamic study. In this article, we briefed the types of analysis carried on the dc-dc converter to study its performance. Moreover, various application of fuel cell is presented and discussed. This paper will be a handbook to the researchers who start to work on high gain dc-dc converter topologies with quadratic boost converter as a base. This article will also guide the engineers to concentrate on the fuel cell components where it needs to be explored for optimizing its operation.
Go to article

Authors and Affiliations

Divya Navamani Jayachandran
1
Jagabar Sathik
2
Tanmay Padhi
1
Aditi Kumari
1

  1. Department of Electrical and Electronics Engineering, SRM Institute of Science and Technology, Kattankulathur, 603203, Chennai, India
  2. Renewable Energy Lab, Prince Sultan University,11586, Riyadh, Saudi Arabia
Download PDF Download RIS Download Bibtex

Abstract

The article is a modified Polish version of my Director’s report published in the “Annual Report 2017–March 2018” of the International Institute of Molecular and Cell Biology in Warsaw (www.iimcb.gov.pl). After 20 years of being in charge of the Institute and a few months before the end of my final term as its director, I summarize our achievements, failures, lost opportunities and recall how it all began. I also give the names of people who formed organizing team of the Institute in the nineties, names of the first International Advisory Board members and names of the Institutes’ directors who will be in charge of it since July 2018.

Go to article

Authors and Affiliations

Jacek Kuźnicki
Download PDF Download RIS Download Bibtex

Abstract

In this work, two thermal- and air-stable, hole transporting materials (HTM) in perovskite solar cells are analyzed. Those obtained and investigated materials were two polyazomethines: the first one with three thiophene rings and 3,3′-dimethoxybenzidine moieties (S9) and the second one with three thiophene rings and fluorene moieties (S7). Furthermore, presented polyazomethines were characterized by Fourier transform infrared spectroscopy (FTIR), UV–vis spectroscopy, atomic force microscopy (AFM) and thermogravimetric analysis (TGA) experiments. Both polyazomethines (S7 and S9) possessed good thermal stability with a 5% weight loss at 406 and 377°C, respectively. The conductivity of S7 was two orders of magnitude higher than for S9 polymer (2.7 × 10−8 S/cm, and 2.6 × 10−10 S/cm, respectively). Moreover, polyazomethine S9 exhibited 31 nm bathochromic shift of the absorption band maximum compared to S7.

Obtained perovskite was investigated by UV–vis and XRD. Electrical parameters of perovskite solar cells (PSC) were investigated at Standard Test Conditions (STC). It was found that both polyazomethines protect perovskite which is confirmed by ageing test where Voc did not decrease significantly for solar cells with HTM in contrast to solar cell without hole conductor, where Voc decrease was substantial. The best photoconversion efficiency (PCE = 6.9%), among two investigated in this work polyazomethines, was obtained for device with the following architectures FTO/TiO2/TiO2 + perovskite/S7/Au. Stability test proved the procreative effects of polyazomethines on perovskite absorber.

Go to article

Authors and Affiliations

K. Gawlinska
A. Iwan
Zbigniew Starowicz
ORCID: ORCID
G. Kulesza-Matla
K. Stan-Glowinska
M. Janusz
M. Lipinski
B. Boharewicz
I. Tazbir
A. Sikora
Download PDF Download RIS Download Bibtex

Abstract

The paper describes factors influencing the development of electricity storage technologies.

The results of the energy analysis of the electric energy storage system in the form of hydrogen are

presented. The analyzed system consists of an electrolyzer, a hydrogen container, a compressor, and

a PEMFC fuel cell with an ion-exchange polymer membrane. The power curves of an electrolyzer

and a fuel cell were determined. The analysis took the own needs of the system into account, i.e. the

power needed to compress the produced hydrogen and the power of the air compressor supplying

air to the cathode channels of the fuel cell stack. The characteristics describing the dependence

of the efficiency of the energy storage system in the form of hydrogen as a function of load were

determined. The costs of electricity storage as a function of storage capacity were determined. The

energy aspects of energy accumulation in lithium-ion cells were briefly characterized and described.

The efficiency of the charge/discharge cycle of lithium-ion batteries has been determined. The

graph of discharge of the lithium-ion battery depending on the current value was presented. The key

parameters of battery operation, i.e. the Depth of Discharge (DoD) and the State of Charge (SoC),

were determined. Based on the average market prices of the available lithium-ion batteries for the

storage of energy from photovoltaic cells, unit costs of electrochemical energy storage as a function

of the DoD parameter were determined.

Go to article

Authors and Affiliations

Bartosz Ceran
Download PDF Download RIS Download Bibtex

Abstract

A microstructural model of Red Blood Cell (RBC) behaviour was proposed. The erythrocyte is treated as a viscoelastic object, which is denoted by a network of virtual particles connected by elastic springs and dampers (Kelvin-Voigt model). The RBC is submerged in plasma modelled by lattice Boltzmann fluid. Fluid – structure interactions are taken into account. The simulations of RBC behaviour during flow in a microchannel and wall impact were performed. The results of RBC deformation during the flow are in good agreement with experimental data. The calculations of erythrocyte disaggregation from the capillary surface show the impact of RBC structure stiffness on the process.

Go to article

Authors and Affiliations

Rafał Przekop
Igor Majewski
Arkadiusz Moskal
Download PDF Download RIS Download Bibtex

Abstract

The aim of the presented research was to test different carbon supports, such as graphene oxide (GO), graphene oxide modified with ammonia (N-GO), and reduced graphene oxide (rGO) for catalysts used in a low-temperature fuel cell, specifically a proton exchange membrane fuel cell (PEMFC). Modification of the carbon supports should lead to different catalytic activity in the fuel cell. Reduction of GO leads to partial removal of oxygen groups from GO, forming rGO. Modification of GO with ammonia results in an enrichment of GO structure with nitrogen. A thorough analysis of the used supports was carried out, using various analytical techniques, such as FTIR spectroscopy and thermogravimetric (TGA) analysis. Palladium and platinum catalysts deposited on these supports were produced and used for the oxygen reduction reaction (ORR). Catalytic activity tests of the prepared catalysts were carried out in a home-made direct formic acid fuel cell (DFAFC). The tests showed that the enrichment of the GO structure with nitrogen caused an increase in the catalytic activity, especially for the palladium catalyst. However, reduction of GO resulted in catalysts with higher activity and the highest catalytic activity was demonstrated by Pt/rGO, because platinum is the most catalytically active metal for ORR. The obtained results may be significant for low-temperature fuel cell technology, because they show that a simple modification of a carbon support may lead to a significant increase of the catalyst activity. This could be useful especially in lowering the cost of fuel cells, which is an important factor, because thousands of fuel cells running on hydrogen are already in use in commercial vehicles, forklifts, and backup power units worldwide. Another method used for lowering the price of current fuel cells can involve developing new clean and cheap production methods of the fuel, i.e. hydrogen. One of them employs catalytic processes, where carbon materials can be also used as a support and it is necessary to know how they can influence catalytic activity.

Go to article

Authors and Affiliations

Zuzanna Bojarska
Marta Mazurkiewicz-Pawlicka
Łukasz Makowski
Download PDF Download RIS Download Bibtex

Abstract

The present study deals with modelling and validation of a planar Solid Oxide Fuel Cell (SOFC) design fuelled by gas mixture of partially pre-reformed methane. A 3D model was developed using the ANSYS Fluent Computational Fluid Dynamics (CFD) tool that was supported by an additional Fuel Cell Tools module. The governing equations for momentum, heat, gas species, ion and electron transport were implemented and coupled to kinetics describing the electrochemical and reforming reactions. In the model, the Water Gas Shift reaction in a porous anode layer was included. Electrochemical oxidation of hydrogen and carbon monoxide fuels were both considered. The developed model enabled to predict the distributions of temperature, current density and gas flow in the fuel cell.

Go to article

Authors and Affiliations

Zdzisław Jaworski
Paulina Pianko-Oprych
Tomasz Zinko
Download PDF Download RIS Download Bibtex

Abstract

By the method of modern physical material science (optic microscopy scanning and transmission electron microscopy) the analysis of structural phase states, the morphology of the second phase inclusions and defect substructure of Al-Si alloy (silumin) of hypoeutectic composition, subjected to electron beam processing was done with the following parameters: energy density 25-35 J/cm2, beam length 150 μs, pulse number – 3, pulse repetition rate – 0.3 Hz, pressure of residual gas (argon) 0.02 Pa. The surface irradiation results in the melting of the surface layer, the dissolution of boundary inclusions, the stricture formation of high speed cellular crystallization of submicron sizes, the repeated precipitation of the second phase nanodimentional particles. With the increased distance from the irradiation surface the layer containing the second phase inclusions of quasi-equilibrium shape along with the crystallization cells was revealed. It is indicative of the processes of Al-Si alloy structure globalization on electron beam processing.

Go to article

Authors and Affiliations

S. Konovalov
V. Gromov
D. Zaguliyaev
Y. Ivanov
A. Semin
J. Rubannikova
Download PDF Download RIS Download Bibtex

Abstract

One of the most common reasons for horse lameness is subchondral bone cysts (SBCs), which are especially evident in young horse athletes. It is believed that SBC development is strongly associated with an individual’s bone growth and/or bone microstructure impairment. Current methods of SBC treatment include pharmacological treatment or surgical procedures which may allow the bone within the cyst to rebuild and be restored to properly developed bone tissue. Thus, we propose filling the SBCs with a 3D complex of alginate hydrogel and autologous adipose derived mesenchymal stem cells (ASCs). We have observed at the in vitro level, that this hydrogel complex induces osteogenic and chondrogenic differentiation potential through the upregulation of bone morphogenetic protein, osteopontin, collagen type I and aggrecan mRNA levels. Moreover, we detected the creation of a 3D extracellular matrix (EM). To investigate the complex in vivo, we chose 8 horses of varying age suffering from SBC, which resulted in lameness, to undergo experimental surgery. We documented the horses’ clinical appearance, lameness and radiographic appearance, to determine that there was clinical improvement in 87.75% of the patients (n=7, out of 8 horses) 6 months postoperatively and 100% (n=8, out of 8 horses) a year after surgery. These results are promising for the potential of this procedure to become the standard in SBC treatment.
Go to article

Authors and Affiliations

P. Golonka
M. Szklarz
M. Kusz
M. Marędziak
J.M. Irwin Houston
K. Marycz
Download PDF Download RIS Download Bibtex

Abstract

The main purpose of the study was to determine the safety of oclacitinib (OCL), a Janus kinase inhibitor, with respect of its effect on CD4 + and CD8 + T cells as well as B cells in the lymphoid tissue. The mice were treated orally with OCL at a dose of 2.7 mg/kg for 14 days and peripheral blood, head and neck lymph nodes (HNLNs), mediastinal lymph nodes (MLNs) and spleen were collected. The study found that OCL induced depletion of CD4 + T cells in the HNLNs and MLNs, while it did not affect the absolute count of CD8 + T cells in these tissues. Also OCL caused a loss of B cells in the HNLNs, although not in the MLNs. Moreover, OCL depleted B cells in the peripheral blood, but did not affect the absolute count of CD4 + and CD8 + T cells. Thus, it can be concluded that OCL may induce a depletive effect on CD4 + and CD8 + T cells as well as B cells in the lymphoid tissue. This effect should be seen as an unfavorable one, especially in patients with infections. Therefore, a clinical implication is that in such patients, the benefit/risk ratio should be thoroughly considered by clinicians. Moreover, OCL reduced the absolute count of eosinophils, basophils, neutrophils and monocytes. However, it is uncertain whether this effect should be considered to be of clinical importance because the levels of these cells were within the physiological range. It is possible that the depletive effect of OCL toward T and B cells, as well as eosinophils and basophils may contribute to the beneficial effects of the drug in the treatment of skin allergic diseases.
Go to article

Bibliography

  1. Apoquel® Summary of Product Characteristics available here: www.ema.europa.eu/en/documents/product-information/apoquel-epar-product-information_en.pdf.
  2. Banovic F, Tarigo J, Gordon H, Barber JP, Gogal RM Jr (2019) Immunomodulatory in vitro effects of oclacitinib on canine T-cell proliferation and cytokine production. Vet Dermatol 30: 17-e6.
  3. Barry M, Bleackley RC (2002) Cytotoxic T lymphocytes: all roads lead to death. Nat Rev Immunol 2: 401-409.
  4. Benucci M, Bernardini P, Coccia C, De Luca R, Levani J, Economou A, Damiani A, Russo E, Amedei A, Guiducci S, Bartoloni E, Manfredi M, Grossi V, Infantino M, Perricone C (2023) JAK inhibitors and autoimmune rheumatic diseases. Autoimmun Rev 22: 103276.
  5. Cetkovic-Cvrlje M, Olson M, Ghate K (2012) Targeting Janus tyrosine kinase 3 (JAK3) with an inhibitor induces secretion of TGF-β by CD4+ T cells. Cell Mol Immunol 9: 350-360.
  6. De Caro Martins G, da Costa-Val AP, Coura FM, Diamantino GM, Nogueira MM, de Oliveira Melo-Junior OA, Giunchetti RC, da Silveira-Lemos D, Melo MM (2022) Immunomodulatory effect of long-term oclacitinib maleate therapy in dogs with atopic dermatitis. Vet Dermatol 33: 142-e40.
  7. Denti D, Caldin M, Ventura L, De Lucia M (2022) Prolonged twice-daily administration of oclacitinib for the control of canine atopic dermatitis: a retrospective study of 53 client-owned atopic dogs. Vet Dermatol 33: 149-e42.
  8. Gonzales AJ, Bowman JW, Fici GJ, Zhang M, Mann DW, Mitton-Fry M (2014) Oclacitinib (APOQUEL(®)) is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. J Vet Pharmacol Ther 37: 317-324.
  9. Gottlieb SL, Martin DH, Xu F, Byrne GI, Brunham RC (2010) Summary: The natural history and immunobiology of Chlamydia trachomatis genital infection and implications for Chlamydia control. J Infect Dis 201 Suppl 2: S190-204.
  10. Hamann D, Baars PA, Rep MH, Hooibrink B, Kerkhof-Garde SR, Klein MR, van Lier RA (1997) Phenotypic and functional separation of memory and effector human CD8+ T cells. J Exp Med 186: 1407-1418.
  11. Hashimoto T, Yokozeki H, Karasuyama H, Satoh T (2023) IL-31–generating network in atopic dermatitis comprising macrophages, basophils, thymic stromal lymphopoietin, and periostin. J Allergy Clin Immunol 151: 737-746.
  12. James JM, Kagey-Sobotka A, Sampson HA (1993) Patients with severe atopic dermatitis have activated circulating basophils. J Allergy Clin Immunol 91: 1155-1162.
  13. Jasiecka-Mikołajczyk A, Jaroszewski JJ, Maślanka T (2018) Oclacitinib depletes canine CD4+ and CD8+ T cells in vitro. Res Vet Sci 121: 124-129.
  14. Jasiecka-Mikołajczyk A, Jaroszewski JJ, Maślanka T (2021) Oclacitinib, a Janus Kinase Inhibitor, Reduces the Frequency of IL-4- and IL-10-, but Not IFN-γ-, Producing Murine CD4+ and CD8+ T Cells and Counteracts the Induction of Type 1 Regulatory T Cells. Molecules 26: 5655.
  15. Lee S, Shah T, Yin C, Hochberg J, Ayello J, Morris E, van de Ven C, Cairo MS (2018) Ruxolitinib significantly enhances in vitro apoptosis in Hodgkin lymphoma and primary mediastinal B-cell lymphoma and survival in a lymphoma xenograft murine model. Oncotarget 9: 9776-9788.
  16. Majewska A, Dembele K, Dziendzikowska K, Prostek A, Gajewska M (2022) Cytokine and Lymphocyte Profiles in Dogs with Atopic Dermatitis after Allergen-Specific Immunotherapy. Vaccines (Basel) 10: 1037.
  17. Majewska A, Gajewska M, Dembele K, Maciejewski H, Prostek A, Jank M (2016) Lymphocytic, cytokine and transcriptomic profiles in peripheral blood of dogs with atopic dermatitis. BMC Vet Res 12: 174.
  18. Maślanka T, Otrocka-Domagała I, Zuśka-Prot M, Mikiewicz M, Przybysz J, Jasiecka A, Jaroszewski JJ (2016) IκB kinase β inhibitor, IMD-0354, prevents allergic asthma in a mouse model through inhibition of CD4(+) effector T cell responses in the lung-draining mediastinal lymph nodes. Eur J Pharmacol 775: 78-85.
  19. Nuttall TJ, Knight PA, McAleese SM, Lamb JR, Hill PB (2002) Expression of Th1, Th2 and immunosuppressive cytokine gene transcripts in canine atopic dermatitis. Clin Exp Allergy 32: 789-795.
  20. Olivry T, Dean GA, Tompkins MB, Dow JL, Moore PF (1999) Toward a canine model of atopic dermatitis: amplification of cytokine-gene transcripts in the skin of atopic dogs. Exp Dermatol 8: 204-211.
  21. Olivry T, Naydan DK, Moore PF (1997) Characterization of the cutaneous inflammatory infiltrate in canine atopic dermatitis. Am J Dermatopathol 19: 477-486.
  22. Ramirez GA, Yacoub MR, Ripa M, Mannina D, Cariddi A, Saporiti N, Ciceri F, Castagna A, Colombo G, Dagna L (2018) Eosinophils from Physiology to Disease: A Comprehensive Review. Biomed Res Int 2018: 9095275.
  23. Reagan-Shaw S, Nihal M, Ahmad N (2007) Dose translation from animal to human studies revisited. FASEB J 22: 659-661.
  24. Schlotter YM, Rutten VP, Riemers FM, Knol EF, Willemse T (2011) Lesional skin in atopic dogs shows a mixed Type-1 and Type-2 immune responsiveness. Vet Immunol Immunopathol 143: 20-26.
  25. Sinke JD, Thepen T, Bihari IC, Rutten VP, Willemse T (1997) Immunophenotyping of skin-infiltrating T-cell subsets in dogs with atopic dermatitis. Vet Immunol Immunopathol 57: 13-23.
  26. Stosović R, Bogić M (1998) The role of eosinophilic leukocytes in allergic inflammation. Srp Arh Celok Lek 126: 130-137.
  27. Wada T, Ishiwata K, Koseki H, Ishikura T, Ugajin T, Ohnuma N, Obata K, Ishikawa R, Yoshikawa S, Mukai K, Kawano Y, Minegishi Y, Yokozeki H, Watanabe N, Karasuyama H (2010) Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks. J Clin Invest 120: 2867-2875.
  28. Wang S, Li H, Lian Z, Deng S (2023) The Role of m6A Modifications in B-Cell Development and B-Cell-Related Diseases. Int J Mol Sci 24: 4721.
  29. Weller PF, Spencer LA (2017) Functions of tissue-resident eosinophils. Nat Rev Immunol 17: 746-760.
Go to article

Authors and Affiliations

A. Jasiecka-Mikołajczyk
1
T. Maślanka
1

  1. Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13, 10-718 Olsztyn, Poland

This page uses 'cookies'. Learn more