The possibilities of practical application of transgenic mammalian species generated by somatic cell cloning in pharmacology, veterinary medicine and xenotransplantology

Journal title

Polish Journal of Veterinary Sciences




No 2


Divisions of PAS

Nauki Biologiczne i Rolnicze


Polish Academy of Sciences Committee of Veterinary Sciences ; University of Warmia and Mazury in Olsztyn




DOI: 10.2478/v10181-011-0051-6 ; ISSN 1505-1773


Polish Journal of Veterinary Sciences; 2011; No 2


J Bates (2004), Tamm-Horsfall protein knockout mice are more prone to urinary tract infection: rapid communication, Kidney Int, 65, 791, ; K Bondioli (2001), Cloned pigs generated from cultured skin fibroblasts derived from a H-transferase transgenic boar, Mol Reprod Dev, 60, 189, ; S Chen (2002), Efficient production of transgenic cloned calves using preimplantation screening, Biol Reprod, 67, 1488, ; A Crecelius (2008), The brain proteome profile is highly conserved between Prnp-/- and Prnp+/+ mice, Neuroreport, 19, 1027, ; J Criado (2005), Mice devoid of prion protein have cognitive deficits that are rescued by reconstitution of PrP in neurons, Neurobiol Dis, 19, 255, ; C Crozet (2004), Inhibition of PrPSc formation by lentiviral gene transfer of PrP containing dominant negative mutations, J Cell Sci, 117, 5591, ; Y Dai (2002), Targeted disruption of the α1,3-galactosyltransferase gene in cloned pigs, Nat Biotechnol, 20, 251, ; C Denning (2001a), Gene targeting in primary fetal fibroblasts from sheep and pig, Cloning Stem Cells, 3, 221, ; C Denning (2001b), Deletion of the α(1,3)galactosyl transferase (GGTA1) gene and the prion protein (PrP) gene in sheep, Nat Biotechnol, 19, 559, ; M Dyck (1999), Seminal vesicle production and secretion of growth hormone into seminal fluid, Nat Biotechnol, 17, 1087, ; Y Echelard (2006), Production of recombinant therapeutic proteins in the milk of transgenic animals, BioPharm International, 19, 36. ; U Galili (2001), The α-gal epitope (Gal α1-3Galβ1-4GlcNAc-R) in xenotransplantation, Biochimie, 83, 557, ; M Golding (2006), Suppression of prion protein in livestock by RNA interference, Proc Natl Acad Sci USA, 103, 5285, ; Huang YJ, Chretien N, Bilodeau AS, Zhou JF, Lazaris A, Karatzas CN (<b>2005</b>) Goat uromodulin promoter directs kidney-specific expression of GFP gene in transgenic mice. BMC Biotechnol 5, published online, doi: 10.1186/1472-6750-5-9: 9-21. ; S Hyun (2003), Production of nuclear transfer-derived piglets using porcine fetal fibroblasts transfected with the enhanced green fluorescent protein, Biol Reprod, 69, 1060, ; D Joziasse (1999), Xenotransplantation: the importance of the Galα1,3Gal epitope in hyperacute vascular rejection, Biochim Biophys Acta, 1455, 403. ; Y Kang (2001), Typical demethylation events in cloned pig embryos. Clues on species-specific differences in epigenetic reprogramming of a cloned donor genome, J Biol Chem, 276, 39980, ; C Keefer (2001), Generation of dwarf goat (Capra hircus) clones following nuclear transfer with transfected and nontransfected fetal fibroblasts and in vitro-matured oocytes, Biol Reprod, 64, 849, ; D Kerr (1998), The bladder as a bioreactor: urothelium production and secretion of growth hormone into urine, Nat Biotechnol, 16, 75, ; A Kind (2008), Animal pharming, two decades on, Transgenic Res, 17, 1025, ; D Kolber-Simonds (2004), Production of α-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations, Proc Natl Acad Sci USA, 101, 7335, ; D Kwon (2006), Cloning and molecular dissection of the 8.8 kb pig uroplakin II promoter using transgenic mice and RT4 cells, J Cell Biochem, 99, 462, ; L Lai (2002), Production of α-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning, Science, 295, 1089, ; G Lee (2005), Production of transgenic cloned piglets from genetically transformed fetal fibroblasts selected by green fluorescent protein, Theriogenology, 63, 973, ; J Lee (2003), Production of cloned pigs by whole-cell intracytoplasmic microinjection, Biol Reprod, 69, 995, ; J Lin (1995), A tissue-specific promoter that can drive a foreign gene to express in the suprabasal urothelial cells of transgenic mice, Proc Natl Acad Sci USA, 92, 679, ; B Lobão-Soares (2007), Cellular prion protein regulates the motor behaviour performance and anxiety-induced responses in genetically modified mice, Behav Brain Res, 183, 87, ; M Mann (2003), Disruption of imprinted gene methylation and expression in cloned preimplantation stage mouse embryos, Biol Reprod, 69, 902, ; K McCreath (2000), Production of gene-targeted sheep by nuclear transfer from cultured somatic cells, Nature, 405, 1066, ; H Meade (1998), Urine as a substitute for milk?, Nat Biotechnol, 16, 21, ; E Melo (2007), Animal transgenesis: state of the art and applications, J Appl Genet, 48, 47, ; J Mills (1987), A secretory protease inhibitor requires androgens for its expression in male sex accessory tissues but is expressed constitutively in pancreas, EMBO J, 6, 3711. ; H Niemann (2007), Transgenic farm animals: an update, Reprod Fertil Dev, 19, 762, ; R Paleyanda (1997), Transgenic pigs produce functional human factor VIII in milk, Nat Biotechnol, 15, 971, ; C Phelps (2003), Production of α1,3-galactosyltransferase-deficient pigs, Science, 299, 411, ; A Powell (2008), Alterations in Ca<sup>2+</sup>-buffering in prion-null mice: association with reduced afterhyperpolarizations in CA1 hippocampal neurons, J Neurosci, 28, 3877, ; J Ramsoondar (2003), Production of α1,3-galactosyltransferase-knockout cloned pigs expressing human α1,2-fucosylosyltransferase, Biol Reprod, 69, 437, ; Z Ryoo (2001), Expression of recombinant human granulocyte macrophage-colony stimulating factor (hGM-CSF) in mouse urine, Transgenic Res, 10, 193, ; M Samiec (2003), Effect of activation treatments on the in vitro developmental potential of porcine nuclear transfer embryos, Czech J Anim Sci, 48, 499. ; M Samiec (2004), Development of pig cloning studies: past, present and future, J Anim Feed Sci, 13, 211. ; M Samiec (2005), The effect of mitochondrial genome on architectural remodeling and epigenetic reprogramming of donor cell nuclei in mammalian nuclear transfer-derived embryos, J Anim Feed Sci, 14, 393. ; F Santos (2004), Epigenetic reprogramming during early development in mammals, Reproduction, 127, 643, ; A Schnieke (1997), Human factor IX transgenic sheep produced by transfer of nuclei from transfected fetal fibroblasts, Science, 278, 2130, ; A Sharma (1994), An isologous porcine promoter permits high level expression of human hemoglobin in transgenic swine, Biotechnology (NY), 12, 55, ; A Sharma (2003), Pig cells that lack the gene for α-1,3-galactosyltransferase express low levels of the gal antigen, Transplantation, 75, 430, ; W Shi (2004), Methylation reprogramming and chromosomal aneuploidy in in vivo fertilized and cloned rabbit preimplantation embryos, Biol Reprod, 71, 340, ; M Skrzyszowska (2006), Generation of transgenic rabbits by the novel technique of chimeric somatic cell cloning, Biol Reprod, 74, 1114, ; M Skrzyszowska (2008), Development of porcine transgenic nuclear-transferred embryos derived from fibroblast cells transfected by the novel technique of nucleofection or standard lipofection, Theriogenology, 70, 248, ; M Swanson (1992), Production of functional human hemoglobin in transgenic swine, Biotechnology (NY), 10, 557, ; A Thomson (2003), Gene targeting in livestock, Reprod Suppl, 61, 495. ; Wang B, Zhou J (<b>2003</b>) Specific genetic modifications of domestic animals by gene targeting and animal cloning. Reprod Biol Endocrinol 1, published online, doi: 10.1186/1477-7827-1-103: 103-110. ; C Weissmann (2003), PrP knock-out and PrP transgenic mice in prion research, Br Med Bull, 66, 43, ; A Wrathall (2000), Risks of transmission of spongiform encephalopathies by reproductive technologies in domesticated ruminants, Livest Prod Sci, 62, 287, ; G Yu (2006), Functional disruption of the prion protein gene in cloned goats, J Gen Virol, 87, 1019, ; H Zbikowska (2002a), The use of the uromodulin promoter to target production of recombinant proteins into urine of transgenic animals, Transgenic Res, 11, 425, ; H Zbikowska (2002b), Uromodulin promoter directs high-level expression of biologically active human α1-antitrypsin into mouse urine, Biochem J, 365, 7, ; J Zhang (2002), Identification of human uroplakin II promoter and its use in the construction of CG8840, a urothelium-specific adenovirus variant that eliminates established bladder tumors in combination with docetaxel, Cancer Res, 62, 3743. ; C Zhu (2009), Production of Prnp-/- goats by gene targeting in adult fibroblasts, Transgenic Res, 18, 163, ; H Zhu (2003a), Targeting gene expression of the mouse uroplakin II promoter to human bladder cells, Urol Res, 31, 17. ; H Zhu (2004), Cloning and analysis of human UroplakinII promoter and its application for gene therapy in bladder cancer, Cancer Gene Ther, 11, 263, ; X Zhu (2002), Isolation of mouse THP gene promoter and demonstration of its kidney-specific activity in transgenic mice, Am J Physiol Renal Physiol, 282. ; X Zhu (2003b), Renal tubule-specific expression and urinary secretion of human growth hormone: a kidney-based transgenic bioreactor, Transgenic Res, 12, 155,