Title

RAGE and Diaph1 deficiency affect retinal cytoarchitecture both in physiological and long-term hyperglycemic settings in diabetic mice – a preliminary study

Journal title

Polish Journal of Veterinary Sciences

Yearbook

2026

Volume

Vol. 29

Issue

No. 1

Authors

Mizia, P. ; Kordas, B. ; Mazur, U. ; Jarosławska-Miszkiewicz, J. ; Szyryńska, N. ; Wąsowicz, K. ; Juranek, J.K.

Affiliation

Mizia, P. : Department of Human Physiology and Pathophysiology, School of Medicine, University of Warmia and Mazury in Olsztyn, Warszawska 30, 10-085, Olsztyn, Poland ; Kordas, B. : Department of Human Physiology and Pathophysiology, School of Medicine, University of Warmia and Mazury in Olsztyn, Warszawska 30, 10-085, Olsztyn, Poland ; Mazur, U. : Department of Human Physiology and Pathophysiology, School of Medicine, University of Warmia and Mazury in Olsztyn, Warszawska 30, 10-085, Olsztyn, Poland ; Jarosławska-Miszkiewicz, J. : Department of Biological Functions of Food, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Władysława Trylińskiego 18, 10-683 Olsztyn Olsztyn, Poland ; Szyryńska, N. : Department of Histology and Embryology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13, 10-713 Olsztyn, Poland ; Wąsowicz, K. : Department of Pathophysiology, Forensic and Administration of Veterinary Medicine, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13, 10-713, Olsztyn, Poland ; Juranek, J.K. : Department of Human Physiology and Pathophysiology, School of Medicine, University of Warmia and Mazury in Olsztyn, Warszawska 30, 10-085, Olsztyn, Poland

Keywords

cytoarchitecture ; diabetes ; Diaph1 ; receptor for advanced glycation end-products ; retina

Divisions of PAS

Nauki Biologiczne i Rolnicze

Coverage

127–131

Publisher

Polish Academy of Sciences Committee of Veterinary Sciences ; University of Warmia and Mazury in Olsztyn

Bibliography

• Cheung N, Mitchell P and Wong TY (2010) Diabetic retinopathy. Lancet 3769735: 124-136.
• Daffu G, Shen X, Senatus L, Thiagarajan D, Abedini A, Hurtado Del Pozo C, Rosario R, Song F, Friedman RA, Ramasamy R and Schmidt AM (2015) RAGE Suppresses ABCG1Mediated Macrophage Cholesterol Efflux in Diabetes. Diabetes 6412: 4046-4060.
• Dong H, Zhang Y, Huang Y and Deng H (2022) Pathophysiology of RAGE in inflammatory diseases. Front Immunol 13: 931473.
• Juranek JK, Aleshin A, Rattigan EM, Johnson L, Qu W, Song F, Ananthakrishnan R, Quadri N, Yan SD, Ramasamy R, Schmidt AM and Geddis MS (2010) Morphological Changes and Immunohistochemical Expression of RAGE and its Ligands in the Sciatic Nerve of Hyperglycemic Pig (Sus Scrofa). Biochem Insights 20103: 47-59.
• Juranek JK, Geddis MS, Rosario R and Schmidt AM (2013) Impaired slow axonal transport in diabetic peripheral nerve is independent of RAGE. Eur J Neurosci 388: 3159-3168.
• Juranek JK, Geddis MS, Song F, Zhang J, Garcia J, Rosario R, Yan SF, Brannagan TH and Schmidt AM (2013) RAGE deficiency improves postinjury sciatic nerve regeneration in type 1 diabetic mice. Diabetes 623: 931-943.
• Kumari N, Karmakar A, Chakrabarti S and Ganesan SK (2020) Integrative Computational Approach Revealed Crucial Genes Associated With Different Stages of Diabetic Retinopathy. Front Genet 11: 576442.
• Lee JH, Park JH, Nam TW, Seo SM, Kim JY, Lee HK, Han JH, Park SY, Choi YK and Lee HW (2018) Differences between immunodeficient mice generated by classical gene targeting and CRISPR/Cas9-mediated gene knockout. Transgenic research 273: 241-251.
• Lu Q, Lu L, Chen W, Chen H, Xu X and Zheng Z (2015) RhoA/mDia-1/profilin-1 signaling targets microvascular endothelial dysfunction in diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol 2535: 669-680.
• Lu Q, Lu P, Chen W, Lu L and Zheng Z (2018) ANGPTL-4 induces diabetic retinal inflammation by activating Profilin-1. Exp Eye Res 166: 140-150.
• Lu Z, Fan B, Li Y and Zhang Y (2023) RAGE plays key role in diabetic retinopathy: a review. Biomed Eng Online 221: 128.
• Mao Y (2011) FORMIN a link between kinetochores and microtubule ends. Trends Cell Biol 2111: 625-629.
• Palander O and Trimble WS (2020) DIAPH1 regulates ciliogenesis and trafficking in primary cilia. FASEB J 3412: 16516-16535.
• Rai V, Maldonado AY, Burz DS, Reverdatto S, Yan SF, Schmidt AM and Shekhtman A (2012) Signal transduction in receptor for advanced glycation end products (RAGE): solution structure of C-terminal rage (ctRAGE) and its binding to mDia1. J Biol Chem 2877: 5133-5144.
• Schmidt AM, Hofmann M, Taguchi A, Yan SD and Stern DM (2000) RAGE: a multiligand receptor contributing to the cellular response in diabetic vasculopathy and inflammation. Seminars in thrombosis and hemostasis 265: 485-493.
• Sharma A, Valle M L, Beveridge C, Liu Y and Sharma S (2019) Unraveling the role of genetics in the pathogenesis of diabetic retinopathy. Eye (Lond) 334: 534-541.
• Takagi H (2003) Molecular mechanisms of retinal neovascularization in diabetic retinopathy. Intern Med 423: 299-301.
• Wang Y, Vom Hagen F, Pfister F, Bierhaus A, Feng Y, Gans R and Hammes H P (2008) Receptor for advanced glycation end product expression in experimental diabetic retinopathy. Annals of the New York Academy of Sciences 1126: 42-45.

Date

17.03.2026

Type

Short communication

Identifier

DOI: 10.24425/pjvs.2026.158507