Details

PDF BIBTEX RIS

Title

Depletion of T and B cells in lymphoid tissues of mice induced by oclacitinib, a Janus kinase inhibitor

Journal title

Polish Journal of Veterinary Sciences

Yearbook

2023

Volume

vol. 26

Issue

No 3

Authors

Jasiecka-Mikołajczyk, A. ; Maślanka, T.

Affiliation

Jasiecka-Mikołajczyk, A. : Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13, 10-718 Olsztyn, Poland ; Maślanka, T. : Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13, 10-718 Olsztyn, Poland

Keywords

B cells ; CD4+ T cells ; CD8+ T cells ; Janus kinase inhibitor ; lymphoid tissue ; oclacitinib

Divisions of PAS

Nauki Biologiczne i Rolnicze

Coverage

431–440

Publisher

Polish Academy of Sciences Committee of Veterinary Sciences ; University of Warmia and Mazury in Olsztyn

Bibliography

  1. Apoquel® Summary of Product Characteristics available here: www.ema.europa.eu/en/documents/product-information/apoquel-epar-product-information_en.pdf.
  2. Banovic F, Tarigo J, Gordon H, Barber JP, Gogal RM Jr (2019) Immunomodulatory in vitro effects of oclacitinib on canine T-cell proliferation and cytokine production. Vet Dermatol 30: 17-e6.
  3. Barry M, Bleackley RC (2002) Cytotoxic T lymphocytes: all roads lead to death. Nat Rev Immunol 2: 401-409.
  4. Benucci M, Bernardini P, Coccia C, De Luca R, Levani J, Economou A, Damiani A, Russo E, Amedei A, Guiducci S, Bartoloni E, Manfredi M, Grossi V, Infantino M, Perricone C (2023) JAK inhibitors and autoimmune rheumatic diseases. Autoimmun Rev 22: 103276.
  5. Cetkovic-Cvrlje M, Olson M, Ghate K (2012) Targeting Janus tyrosine kinase 3 (JAK3) with an inhibitor induces secretion of TGF-β by CD4+ T cells. Cell Mol Immunol 9: 350-360.
  6. De Caro Martins G, da Costa-Val AP, Coura FM, Diamantino GM, Nogueira MM, de Oliveira Melo-Junior OA, Giunchetti RC, da Silveira-Lemos D, Melo MM (2022) Immunomodulatory effect of long-term oclacitinib maleate therapy in dogs with atopic dermatitis. Vet Dermatol 33: 142-e40.
  7. Denti D, Caldin M, Ventura L, De Lucia M (2022) Prolonged twice-daily administration of oclacitinib for the control of canine atopic dermatitis: a retrospective study of 53 client-owned atopic dogs. Vet Dermatol 33: 149-e42.
  8. Gonzales AJ, Bowman JW, Fici GJ, Zhang M, Mann DW, Mitton-Fry M (2014) Oclacitinib (APOQUEL(®)) is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. J Vet Pharmacol Ther 37: 317-324.
  9. Gottlieb SL, Martin DH, Xu F, Byrne GI, Brunham RC (2010) Summary: The natural history and immunobiology of Chlamydia trachomatis genital infection and implications for Chlamydia control. J Infect Dis 201 Suppl 2: S190-204.
  10. Hamann D, Baars PA, Rep MH, Hooibrink B, Kerkhof-Garde SR, Klein MR, van Lier RA (1997) Phenotypic and functional separation of memory and effector human CD8+ T cells. J Exp Med 186: 1407-1418.
  11. Hashimoto T, Yokozeki H, Karasuyama H, Satoh T (2023) IL-31–generating network in atopic dermatitis comprising macrophages, basophils, thymic stromal lymphopoietin, and periostin. J Allergy Clin Immunol 151: 737-746.
  12. James JM, Kagey-Sobotka A, Sampson HA (1993) Patients with severe atopic dermatitis have activated circulating basophils. J Allergy Clin Immunol 91: 1155-1162.
  13. Jasiecka-Mikołajczyk A, Jaroszewski JJ, Maślanka T (2018) Oclacitinib depletes canine CD4+ and CD8+ T cells in vitro. Res Vet Sci 121: 124-129.
  14. Jasiecka-Mikołajczyk A, Jaroszewski JJ, Maślanka T (2021) Oclacitinib, a Janus Kinase Inhibitor, Reduces the Frequency of IL-4- and IL-10-, but Not IFN-γ-, Producing Murine CD4+ and CD8+ T Cells and Counteracts the Induction of Type 1 Regulatory T Cells. Molecules 26: 5655.
  15. Lee S, Shah T, Yin C, Hochberg J, Ayello J, Morris E, van de Ven C, Cairo MS (2018) Ruxolitinib significantly enhances in vitro apoptosis in Hodgkin lymphoma and primary mediastinal B-cell lymphoma and survival in a lymphoma xenograft murine model. Oncotarget 9: 9776-9788.
  16. Majewska A, Dembele K, Dziendzikowska K, Prostek A, Gajewska M (2022) Cytokine and Lymphocyte Profiles in Dogs with Atopic Dermatitis after Allergen-Specific Immunotherapy. Vaccines (Basel) 10: 1037.
  17. Majewska A, Gajewska M, Dembele K, Maciejewski H, Prostek A, Jank M (2016) Lymphocytic, cytokine and transcriptomic profiles in peripheral blood of dogs with atopic dermatitis. BMC Vet Res 12: 174.
  18. Maślanka T, Otrocka-Domagała I, Zuśka-Prot M, Mikiewicz M, Przybysz J, Jasiecka A, Jaroszewski JJ (2016) IκB kinase β inhibitor, IMD-0354, prevents allergic asthma in a mouse model through inhibition of CD4(+) effector T cell responses in the lung-draining mediastinal lymph nodes. Eur J Pharmacol 775: 78-85.
  19. Nuttall TJ, Knight PA, McAleese SM, Lamb JR, Hill PB (2002) Expression of Th1, Th2 and immunosuppressive cytokine gene transcripts in canine atopic dermatitis. Clin Exp Allergy 32: 789-795.
  20. Olivry T, Dean GA, Tompkins MB, Dow JL, Moore PF (1999) Toward a canine model of atopic dermatitis: amplification of cytokine-gene transcripts in the skin of atopic dogs. Exp Dermatol 8: 204-211.
  21. Olivry T, Naydan DK, Moore PF (1997) Characterization of the cutaneous inflammatory infiltrate in canine atopic dermatitis. Am J Dermatopathol 19: 477-486.
  22. Ramirez GA, Yacoub MR, Ripa M, Mannina D, Cariddi A, Saporiti N, Ciceri F, Castagna A, Colombo G, Dagna L (2018) Eosinophils from Physiology to Disease: A Comprehensive Review. Biomed Res Int 2018: 9095275.
  23. Reagan-Shaw S, Nihal M, Ahmad N (2007) Dose translation from animal to human studies revisited. FASEB J 22: 659-661.
  24. Schlotter YM, Rutten VP, Riemers FM, Knol EF, Willemse T (2011) Lesional skin in atopic dogs shows a mixed Type-1 and Type-2 immune responsiveness. Vet Immunol Immunopathol 143: 20-26.
  25. Sinke JD, Thepen T, Bihari IC, Rutten VP, Willemse T (1997) Immunophenotyping of skin-infiltrating T-cell subsets in dogs with atopic dermatitis. Vet Immunol Immunopathol 57: 13-23.
  26. Stosović R, Bogić M (1998) The role of eosinophilic leukocytes in allergic inflammation. Srp Arh Celok Lek 126: 130-137.
  27. Wada T, Ishiwata K, Koseki H, Ishikura T, Ugajin T, Ohnuma N, Obata K, Ishikawa R, Yoshikawa S, Mukai K, Kawano Y, Minegishi Y, Yokozeki H, Watanabe N, Karasuyama H (2010) Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks. J Clin Invest 120: 2867-2875.
  28. Wang S, Li H, Lian Z, Deng S (2023) The Role of m6A Modifications in B-Cell Development and B-Cell-Related Diseases. Int J Mol Sci 24: 4721.
  29. Weller PF, Spencer LA (2017) Functions of tissue-resident eosinophils. Nat Rev Immunol 17: 746-760.

Type

Article

Identifier

DOI: 10.24425/pjvs.2023.145049
×