Details

Title

Clinical and immunological effects of Malva sylvestris and levamisole combination in the treatment of trichophytosis in cattle

Journal title

Polish Journal of Veterinary Sciences

Yearbook

2026

Volume

Vol. 29

Issue

No. 1

Authors

Affiliation

Dogan, E. : Department of Laboratory and Veterinary Health, Nihat Delibalta Göle Vocational School, University of Ardahan, 75700, Ardahan, Turkey

Keywords

cattle ; dermatophytosis ; levamisole ; malva sylvestris ; trichophyton verrucosum

Divisions of PAS

Nauki Biologiczne i Rolnicze

Coverage

31–38

Publisher

Polish Academy of Sciences Committee of Veterinary Sciences ; University of Warmia and Mazury in Olsztyn

Bibliography

  • Abdullah TK, Wadee SA, Owain MS (2021) Isolation, diagnosis and incidence of ringworm in cattle in salah al-din governorate. Vet Pract 22: 62-64.
  • Afshar M, Ravarian B, Zardast M, Moallem SA, Fard MH, Valavi M (2015) Evaluation of cutaneous wound healing activity of Malva sylvestris aqueous extract in BALB / c mice. Iran J Basic Med Sci 18: 616-622.
  • Al-Farha AA, Mahmood AA (2021) Evaluation of three topical antifungals against bovine ringworm. Vet Pract 22: 41-44.
  • Barros L, Carvalho AM, Ferreira IC (2010) Leaves, flowers, immature fruits and leafy flowered stems of Malva sylvestris: a comparative study of the nutraceutical potential and composition. Food Chem Toxicol 48: 1466-1472.
  • Batiha GE, Tene ST, Teibo JO, Shaheen HM, Oluwatoba OS, Teibo TK, Al-Kuraishy HM, Al-Garbee AI, Alexiou A, Papadakis M (2023) The phytochemical profiling, pharmacological activities, and safety of malva sylvestris: a review. Naunyn Schmiedebergs Arch Pharmacol 396: 421-440.
  • Colakoglu HE, Yazlik MO, Colakoglu EC, Kaya U, Bayramoglu R, Kurt S, Vural R, Kuplulu S (2021) Oxidative stress in cows according to calving season: passive calf immunity and its relationship with colostrum quality. Pol J Vet Sci 24: 225-233.
  • Dogan E (2022) Effects of levamisole application on immunity system in anthrax-vaccinated cattle. Kocatepe Vet J 15: 348-354.
  • Dogan E (2023) Investigation of the effect of malva plant (Malva sylvestris L.) on skin fungus in cattle. Van Vet J 34: 208-212.
  • Feizi S, Taghipour E, Ghadam P, Mohammadi P (2018) Antifungal, antibacterial, antibiofilm and colorimetric sensing of toxic metals activities of eco friendly, economical synthesized Ag/AgCl nanoparticles using Malva Sylvestris leaf extracts. Microb Pathog 125: 33-42.
  • Hajyani S, Modaresi M, Madani M (2015) Effect of Malva sylvestris L. extract on blood cell parameters in mice with candida albicans Infection. Der Pharma Chem 7: 302-305.
  • Hizli H (2020) A study on the use of henna plant (Lawsonia inermis Linn) for the treatment of fungal disease (Trichophypton verrucosum) in calves. J Hellenic Vet Med Soc 71: 2483-2490.
  • Jabri MA, Wannes D, Hajji N, Sakly M, Marzouki L, Sebai H (2017) Role of laxative and antioxidant properties of Malva sylvestris leaves in constipation treatment. Biomed Pharmacother 89: 29-35.
  • Jańczak D, Górecki P, Maj AK (2023) PCR-based methods in detection and identification of dermatophytes in dogs and cats with suspected dermatophytosis in 2021 in Poland. Pol J Vet Sci 26: 629-634.
  • Nowak W, Mikuła R, Zachwieja A, Paczyńska K, Pecka E, Drzazga K, Ślósarz P (2012) The impact of cow nutrition in the dry period on colostrum quality and immune status of calves. Pol J Vet Sci 15: 77-82.
  • Paryuni AD, Indarjulianto S, Widyarini S (2020) Dermatophytosis in companion animals: a review. Vet World 13: 1174-1181.
  • Prudente AS, Sponchiado G, Mendes DA, Soley BS, Cabrini DA, Otuki MF (2017) Pre-clinical efficacy assessment of Malva sylvestris on chronic skin inflammation. Biomed Pharmacother 93: 852-860.
  • Qureshi ZI, Lodhi LA, Jamil H, Nawaz M (2000) Effect of levamisole hydrochloride on serum and colostral antibody titres against foot and mouth disease virus in vaccinated buffaloes (Bubalus bubalis). Vet Arh 70: 59-66.
  • Rao TK, Mohanty TK, Bhakat M (2017) Levamisole as an immunomodulator to ameliorate vaccination stress in crossbred bulls. Indian J Anim Sci 87: 840-843.
  • Rhimi F, Rejili M, Benabderrahim MA, Hannachi H (2025) Diversity of phytochemical content, antioxidant activity, and fruit morphometry of three mallow, Malva species (Malvaceae). Plants-Basel 14: 930.
  • Rudramurthy SM, Shaw D (2017) Overview and update on the laboratory diagnosis of dermatophytosis. Clin Derm Rev 1: S3-S11.
  • Sajid MS, Iqbal Z, Muhammad G, Iqbal MU (2006) Immunomodulatory effect of various anti-parasitics: a review. Parasitology 132: 301–313.
  • Salahi Z, Yadegari MH, Bagheri M, Khani MH, Zahmatkesh A, Khaki P (2020) The effect of cytoplasmic crude extracts of Trichophyton verrucosum on cell mediated immunity. J Mycol Med 30: 100969.
  • Sharma LK, Jagadish S, Mulbagal AN (1990) Effects of haemorrhagic septicaemia vaccination and levamisole administration on the humoral response in cross‐bred calves. J Vet Pharmacol Ther 13: 23-28.
  • Siwicki AK, Cossarini-Dunier M (1990) Effect of levamisole on the lymphocyte and macrophage activity in carp (Cyprinus carpio). Ann Rech Vet 21: 95-100.
  • Tartor YH, El-Neshwy WM, Merwad AM, El-Maati MF, Mohamed RE, Dahshan HM, Mahmoud HI (2020) Ringworm in calves: risk factors, improved molecular diagnosis, and therapeutic efficacy of an Aloe vera gel extract. BMC Vet Res 16: 421.
  • Voigt GL, Swist SL (2011) Hematology techniques and concepts for veterinary technicians. 2nd ed., Wiley-Blackwell, Ames, Iowa, USA.
  • Wu Y, Qiu A, Yang Z, Wu J, Li X, Bao K, Wang M, Wu B (2019) Malva sylvestris extract alleviates the astrogliosis and inflammatory stress in LPS-induced depression mice. J Neuroimmunol 336: 577029.
  • Yildirim BA (2020) Evaluation of biochemical parameters and oxidative stress in native and crossbred cattle naturally infected with dermatophytosis. GSC Biol Pharm Sci 13: 99-104.
  • Zuo H, Li Y, Cui Y, An Y (2017) Cardioprotective effect of Malva sylvestris L. in myocardial ischemic/reprefused rats. Biomed Pharmacother 95: 679-684.

Date

17.03.2026

Type

Article

Identifier

DOI: 10.24425/pjvs.2026.158498
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